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US 2004/0219655 A1Published application
Nanoscale particles synthesized within an assembled virion
AssigneeThe Research and Development Institute, Inc.
InventorsTrevor Douglas, Mark J. Young
Life of this patent
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Abstract
Virion-constrained nanoparticles comprising a shell of virion coat protein(s) surrounding an organic, inorganic and/or organo-metallic non-viral nanoparticle and methods of making and using.
Claims20
A virion-constrained nanoparticle comprising a shell of a virion coat protein surrounding a nanoparticle of non-viral origin.
A process for the production of virion-constrained nanoparticles comprising:
- a) providing an isolated and substantially pure coat protein(s) of a virion;
- b) incubating said coat protein(s) in solution under conditions that permit re-assembly of a virion capsid;
- c) mixing the re-assembled virion with one or more materials selected from the group consisting of organic, inorganic and organo-metallic materials, under conditions that entrap said material to provide virion-constrained nanoparticles surrounded by said virion coat protein;
- and
- d) isolating the virion-constrained nanoparticles so produced.
2 more elements
A process for producing virion-constrained nanoparticles comprising:
- a) providing an isolated and substantially pure coat protein(s) of a virion;
- b) incubating said coat protein(s) in a solution comprising one or more materials selected from the group consisting of organic, inorganic and organo-metallic materials, under conditions that permit assembly of a virion and permit said virion to entrap said material and to provide virion-constrained nanoparticles surrounded by said virion coat protein;
- and
- c) isolating the virion-constrained nanoparticles so produced.
1 more element
A process for producing virion-constrained nanoparticles comprising:
- a) providing isolated and substantially pure virions devoid of viral nucleic acid;
- b) incubating said virions in a solution comprising one or more materials selected from the group consisting of organic, inorganic and organo-metallic materials, under conditions that permit said virion to entrap said material to provide virion-constrained nanoparticles surrounded by said virion;
- and
- c) isolating the virion-constrained nanoparticles so produced.
1 more element
Dependencies are inferred from the claim text.