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OwnerDonald Jackson, Gary L. Schieven +4inventors
InventorsDonald Jackson, Gary L. Schieven, Stanley R. Krystek, John N. Feder, Thomas C. Nelson, Donna A. Bassolino
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The present invention provides novel polynucleotides encoding a human phosphatase polypeptide, BMY_HPP13, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptide. The invention further relates to diagnostic and therapeutic methods for applying this novel human phosphatase polypeptide to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence selected from the group consisting of:
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
An isolated nucleic acid molecule consisting of a polynucleotide having a nucleotide sequence selected from the group consisting of:
An isolated polypeptide consisting of an amino acid sequence selected from the group consisting of:
A method of isolating phosphoproteins or phosphopeptides comprising the steps of passing a sample over a catalytically inactive mutant of the polypeptide provided in SEQ ID NO:2 bound to a support, washing sample material away that did not bind to said polypeptide, and isolating said bound sample by subjecting said bound sample/polypeptide complex under conditions in which said bound sample is released.
A computer for producing a three-dimensional representation of a molecule or molecular complex, wherein said molecule or molecular complex comprises the structural coordinates of the BMY_HPP13 model provided in FIG. 8 in accordance with Table IV wherein said computer comprises:
A method for identifying a mutant with altered biological properties, function, or activity of BMY_HPP13 wherein said method comprises the steps of:
A method for designing or selecting compounds as potential modulators of BMY_HPP13 wherein said method comprises the steps of:
Dependencies are inferred from the claim text.