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US 2004/0204476 A1Published application
Oxopyrrolidine compounds, preparations of said compounds and their use in the manufacturing of levetiracetam and analogues
AssigneeUcb, S.A.
InventorsCelal Ates, John Surtees, Anne-Catherine Burteau, Violeta Marmon, Emile Cavoy
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Abstract
The present invention relates to an improved process for the preparation of (S)-(−)-α-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R2 is C?2#19 1-C?4#191 alkyl, C?2#191 -C?4#191 alkenyl or C?2#191-C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes. 1
Claims30
A compound of formula (6)
- 65
- wherein
- R1 is methyl or ethyl;
- and
- R2 is C2-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, optionally substituted by one or more halogen;
- as well as the stereoisomers and mixtures thereof.
3 more elements
A process for the manufacture of a compound of formula (22′)
- 81
- wherein R2′ is hydrogen, C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, optionally substituted by one or more halogen, said process comprising the ammonolysis of the corresponding compound of formula (6′)
- 82
- wherein R1′ is C1-C6 alkyl and R2′ is hydrogen, C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, optionally substituted by one or more halogen, in the presence of water.
1 more element
Dependencies are inferred from the claim text.