Treatment of diabetes
AssigneeFibroGen, Inc.
InventorsVolkmar Guenzler-Pukall, Stephen J. Klaus, Ingrid Langsetmo Parobok, Todd W. Seeley
Life of this patent
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Abstract
The present invention relates to methods and compounds for regulating glucose metabolism, achieving glucose homeostasis, and decreasing blood glucose levels. Methods and compounds for treating or preventing diabetes, hyperglycemia, and disorders and conditions associated with altered or impaired glucose metabolism are also provided.
Claims37
A method for regulating glucose metabolism or a glucose metabolic process, the method comprising stabilizing HIFα, thereby regulating glucose metabolism or the glucose metabolic process.
A method for regulating glucose metabolism or a glucose metabolic process, the method comprising administering an effective amount of a compound that inhibits HIF hydroxylase activity, thereby regulating glucose metabolism or the glucose metabolic process.
A method for regulating glucose metabolism or a glucose metabolic process in a cell, the method comprising stabilizing HIFα in the cell, thereby regulating glucose metabolism or the glucose metabolic process in the cell.
A method for regulating glucose metabolism or a glucose metabolic process in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity in the cell, thereby regulating glucose metabolism or the glucose metabolic process in the cell.
A method for regulating glucose metabolism or a glucose metabolic process in a subject, the method comprising stabilizing HIFα in the subject, thereby regulating glucose metabolism or a glucose metabolic process in the subject.
A method for regulating glucose metabolism or a glucose metabolic process in a subject, the method comprising administering to the subject an effective amount of a compound that inhibits HIF hydroxylase activity in the subject, thereby regulating glucose metabolism or the glucose metabolic process in the subject.
A method for achieving glucose homeostasis in a subject, the method comprising stabilizing HIFα in the subject, thereby achieving glucose homeostasis in the subject.
A method for decreasing blood glucose levels in a subject, the method comprising stabilizing HIFα in the subject, thereby decreasing blood glucose levels in the subject.
A method for decreasing glycated hemoglobin levels in a subject, the method comprising stabilizing HIFα in the subject, thereby decreasing glycated hemoglobin levels in the subject.
A method for altering expression of a glucose regulatory factor, the method comprising stabilizing HIFα, thereby altering expression of the glucose regulatory factor.
A method for altering expression of a glycolytic factor, the method comprising stabilizing HIFα, thereby altering expression of the glycolytic factor.
A method for treating or preventing diabetes in a subject having or at risk for developing diabetes, the method comprising stabilizing HIFα in the subject, thereby treating or preventing diabetes in the subject.
A method for treating or preventing a disorder associated with increased blood glucose levels in a subject, the method comprising stabilizing HIFα in the subject, thereby treating or preventing the disorder associated with increased blood glucose levels in the subject.
A method for treating or preventing a condition associated with diabetes in a subject, the method comprising stabilizing HIFα in the subject, thereby treating or preventing the condition associated with diabetes.
A method for decreasing blood triglyceride levels in a subject, the method comprising stabilizing HIFα in the subject, thereby decreasing blood triglyceride levels in the subject.
A method for reducing insulin resistance in a subject, the method comprising stabilizing HIFα in the subject, thereby reducing insulin resistance in the subject.
A method for increasing glycemic control in a subject, the method comprising stabilizing HIFα in the subject, thereby increasing glycemic control.
Dependencies are inferred from the claim text.