Coated particles, methods of making and using
AssigneeLyotropic Therapeutics, Inc.
InventorDavid Anderson
Life of this patent
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Abstract
A particle coated with a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material includes an internal matrix core having at least one a nanostructured liquid phase, or at least on nanostructured liquid crystalline phase or a combination of the two is used for the delivery of active agents such as pharmaceuticals, nutrients, pesticides, etc. The coated particle can be fabricated by a variety of different techniques where the exterior coating is a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material
Claims67
1-107. (Cancelled).
A reversed cubic or reversed hexagonal phase material comprising
- water or glycerol or a water/glycerol mixture
- an anesthetic, and
- a surfactant selected from the group consisting of fluorosurfactants, BRIJ-type surfactants, Triton-like surfactants, surfactants with polymer chains, peptide-based surfactants, isoprenoids, plasmologens, cerebrosides, sulphatides, gangliosides, cyclopentatriol lipids, dimethylaminopropane lipids, lysolipids, lysolecithins, anionic surfactants, cationic surfactants, zwitterionic or semipolar surfactants, benzalkonium chloride, sodium deoxycholate, myristyl-gamma-picolinium chloride, polyoxyl 35 castor oil, sorbitan monopalmitate, and sodium 2-ethylhexanoic acid.
A reversed cubic or reversed hexagonal phase material comprising
- water or glycerol or a water/glycerol mixture
- an anesthetic, and
- a phospholipid.
A coated particle comprising an interior core comprising a matrix consisting essentially of
- a) at least one nanostructured liquid phase,
- b) at least one nanostructured liquid crystalline phase or
- c) a combination of
- i) at least one nanostructured liquid phase and
- ii) at least one nanostructured liquid crystalline phase,
- wherein the matrix comprises
- a surfactant or block copolymer
- a polar solvent, and
- an anesthetic.
A cubic phase liquid crystalline material comprising a glycolipid that is capable of binding bacteria.
A coated particle comprising
- a. an interior core comprising a matrix consisting essentially of
- i) at least one nanostructured liquid phase,
- ii) at least one nanostructured liquid crystalline phase or
- iii) a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase,
- wherein at least a portion of said matrix is not a cubic phase but can be converted to a cubic phase, and
- b. an exterior coating comprising a non-lamellar crystalline material.
A non-lamellar coated particle having an interior core comprising a matrix consisting essentially of
- a) at least one nanostructured liquid phase,
- b) at least one nanostructured liquid crystalline phase or
- c) a combination of
- i) at least one nanostructured liquid phase and
- ii) at least one nanostructured liquid crystalline phase, and
- wherein the matrix comprises a surfactant or lipid comprising a polar head group that modifies interfacial physics of an aqueous phase at a polar-apolar interface.
A coated particle comprising
- a) an interior core comprising a matrix consisting essentially of
- i) at least one nanostructured liquid phase,
- ii) at least one nanostructured liquid crystalline phase or
- iii) a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b) an exterior coating comprising a nonlamellar crystalline material,
- wherein the matrix comprises a surfactant having one or more hydrophilic polymer blocks totaling at least 1,000 Daltons in molecular weight.
A coated particle with a core comprising a matrix consisting essentially of a reversed cubic or reversed hexagonal phase comprising
- water or glycerol or a water-glycerol mixture, and
- a nonionic surfactant with a PEG head groups ether-linked to an alkane chain.
A coated particle having an interior core comprising a matrix consisting essentially of
- a) at least on nanostructured liquid phase,
- b) at least one nanostructured liquid crystalline phase or
- c) a combination of
- i) at least one nanostructured liquid phase and
- ii) at least one nanostructured liquid crystalline phase, and
- wherein said matrix comprises a surfactant selected from the group consisting of fluorosurfactants, glycolipids that bind bacteria, BRIJ-type surfactants, Triton-like surfactants, peptide-based surfactants, surfactants, MGDG, DGDG, diacylglucopyranosyl glycerols, gentiobiosyls, isoprenoids, ceramides, plasmologens, cerebrosides, sulphatides, gangliosides, cyclopentatriol lipids, dimethylaminopropane lipids, lysolipids, lysolecithins, anionic surfactants, cationic surfactants, nonionic PEGylated surfactants of the formula CnEm in which C is an alkane chain with n carbon atoms and n ranges from 6 to 20 and E represents ethylene oxide groups of number m and m ranges from 2 to 80, zwitterionic or semipolar surfactants, benzalkonium chloride, sodium deoxycholate, myristyl-gamma-picolinium chloride, polyoxyl 35 castor oil, sorbitan monopalmitate, and sodium 2-ethylhexanoic acid.
A coated particle having an interior core comprising a matrix consisting essentially of
- a) at least one nanostructured liquid phase,
- b) at least one nanostructured liquid crystalline phase or
- c) a combination of
- i) at least one nanostructured liquid phase and
- ii) at least one nanostructured liquid crystalline phase, and
- wherein said nanostructured liquid phase or said nanostructured liquid crystalline phase is made from a surfactant selected from the group consisting of fluorosurfactants, glycolipids that bind bacteria, BRIJ-type surfactants, Triton-like surfactants, peptide-based surfactants, MGDG, DGDG, diacylglucopyranosyl glycerols, gentiobiosyls, isoprenoids, ceramides, plasmologens, cerebrosides, sulphatides, gangliosides, cyclopentatriol lipids, dimethylaminopropane lipids, lysolipids, lysolecithins, anionic surfactants, cationic surfactants, nonionic PEGylated surfactants of the formula CnEm in which C is an alkane chain with n carbon atoms and n ranges from 6 to 20 and E represents ethylene oxide groups of number m and m ranges from 2 to 80, zwitterionic or semipolar surfactants, benzalkonium chloride, sodium deoxycholate, myristyl-gamma-picolinium chloride, polyoxyl 35 castor oil, sorbitan monopalmitate, and sodium 2-ethylhexanoic acid.
A coated particle with a core comprising a matrix consisting essentially of a reversed cubic or reversed hexagonal phase comprising
- water or glycerol or a water-glycerol mixture, and
- a nonionic PEG-based surfactant of low HLB.
A coated particle comprising
- a) an interior core comprising a matrix consisting essentially of a cubic phase, and
- b) an exterior coating comprising a nonlamellar crystalline material,
- wherein the cubic phase comprises polar domains composed substantially of polar moieties comprising water and lipid head groups.
A coated particle with a core comprising a matrix consisting essentially of a reversed cubic or reversed hexagonal phase comprising
- water or glycerol or a water-glycerol mixture, and
- a nonionic PEG-based surfactant or a polyoxyethylene-polyoxypropylene block copolymer which is of low solubility in water.
A coated particle with a core comprising a matrix consisting essentially of a reversed cubic or reversed hexagonal phase comprising
- water or glycerol or a water-glycerol mixture
- a polyoxyethylene-polyoxypropylene block copolymer of low HLB
A coated particle with a core comprising a matrix consisting essentially of a reversed cubic or reversed hexagonal phase comprising
- water or glycerol or a water-glycerol mixture, and
- an amphiphilic block copolymer of low HLB.
Dependencies are inferred from the claim text.