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US 2004/0197351 A1Published application
Avian herpesvirus-based recombinant Infectious Bursal Disease vaccine
AssigneeZeon Corporation
InventorsTakanori Sato, Yoshinari Tsuzaki, Motoyuki Esaki, Kristi M. Dorsey
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Abstract
The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding, the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype 1 strains. The present invention further provides an avian recombinant herpesvirus comprised of the VP2 gene of which the backbone virus is a Marek's disease vaccine strain, such as herpesvirus of turkeys. A poultry vaccine including the avian herpes recombinant virus described in the present invention can induce in chickens protective immunity against a variety of different subtypes of IBDV.
Claims8
1:
- An avian recombinant herpesvirus modified by the insertion of cDNA encoding VP2 of the Delaware Variant E strain of IBDV into the region of the herpesvirus genome which is non-essential for the virus growth.
2:
- An avian recombinant herpesvirus as in claim 1 wherein the sequence of cDNA encoding VP2 is that shown in SEQ ID NO. 1.
3-5 (Canceled).
6:
- An avian recombinant herpesvirus as in claim 1, wherein the said herpesvirus is herpesvirus of turkeys.
7:
- An avian recombinant herpesvirus as in claim 1 wherein said herpesvirus is the SB1 strain of the serotype 2 Marek's disease virus.
8:
- An avian recombinant herpesvirus as in claim 1 wherein the herpesvirus is the Rispens strain of the serotype 1 Marek's disease virus.
9:
- An Infectious Bursal Disease vaccine comprising the avian recombinant herpesvirus as in claim 1.
10 (Canceled).