Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto

A compound having the following structure:

• 61
• or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein:
• R1 is hydrogen, halogen, nitro, cyano, alkyl, substituted alkyl, alkoxy, hydroxy, aryl, substituted aryl, —NHC(═O)R′, heteroaryl or substituted heteroaryl;
• R2, R3, R5 and R6 are the same or different and independently hydrogen, halogen, nitro, cyano, alkyl, substituted alkyl, alkoxy, hydroxy, aryl, substituted aryl, heteroaryl or substituted heteroaryl;
• R4 is hydrogen, halogen, nitro, cyano, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —O—R7, —C(═O)—R7, —C(═O)O—R7, —C(═O)—NH—R7 or —NHC(═O)R″;
• R7 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl or substituted arylalkyl;
• R′ and R″ are the same or different and independently alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl;
• and
• R4 and R5 or R5 and R6, taken together with the carbon atoms to which they are attached, optionally form a substituted or unsubstituted homocycle.