Novel atisane compounds and use thereof

A compound represented by the following formula:

• 173
• (wherein z represents a bivalent organic group of from 2 to 3 carbon atoms, provided that Z may have one or two group(s) selected from the group consisting of those represented by the following formula:
• 174
• (wherein A1 represents an optionally substituted C1-6 alkylene group or a single bond;
• X1 represents a halogen atom or a cyano group;
• X2 represents the formula —S(O)m— (wherein m is an integer of 0, 1 or 2), an oxygen atom, a carbonyl group or a single bond;
• R4a represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group, an optionally substituted C2-6 alkynyl group, an optionally substituted C6-14 aromatic hydrocarbon cyclic group, an optionally substituted from 5- to 14-membered aromatic heterocyclic group, an optionally substituted C1-6 alkoxy group or a hydroxyl group;
• and R4b and R4c are independent of each other and each represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group, an optionally substituted C2-6 alkynyl group, an optionally substituted C6-14 aromatic hydrocarbon cyclic group, an optionally substituted from 5- to 14-membered aromatic heterocyclic group, an optionally substituted C2-7 acyl group or an optionally substituted C1-6 alkylsulfonyl group), and the case where Z is a 1,2-ethylene group not having a substituent or a 1,2-vinylene group not having a substituent is excluded;
• R3a represents a carbonyl group, a methylene group or a single bond;
• and
• R3b represents a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group, an optionally substituted C2-6 alkynyl group, an optionally substituted C1-6 alkoxy group, a hydroxyl group, a cyano group or a group represented by the formula —NR5aR5b (wherein, R5a and R5b are independent of each other and each represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group, an optionally substituted C2-6 alkynyl group, an optionally substituted C6-14 aromatic hydrocarbon cyclic group, an optionally substituted from 5- to 14-membered aromatic heterocyclic group, an optionally substituted C2-7 acyl group or an optionally substituted C1-6 alkylsulfonyl group), provided that the following cases (1) to (3) are excluded:
• (1) Z represents a 1,2-dicarboxyethane-1,2-yl group or a 1,2-dimethoxycarbonylethane-1,2-yl group, and the formula —R3a—R3b represents a hydroxymethyl group or an acetoxymethyl group;
• (2) Z represents a 1-i-propylethane-1,2-yl group and the formula —R3a —R3b represents a hydrogen atom;
• and
• (3) the formula —R3a—R3b represents a methyl group, and Z represents the formula:
• 175
• (wherein R11 represents a hydrogen atom or a methyl group, and R12 represents a hydroxyl group, a methyl group or a tetrahydropyran-2H-pyran-2-yl-oxy group)), a salt thereof or a hydrate of them.