Method for the production of nanodispersions
OwnerKai Christian Jurgens, Bernd Kuhninventors
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Abstract
A method for the production of nanodispersions, in which at least two metered partial streams are brought together in such a way that they are subject to thorough mixing caused by turbulence. The partial streams have a flow rate in the range from 0.1 to 500 ml/h and the mixed stream has an overall flow rate in the range from 1 ml/h to 500 ml/h. The turbulent mixing leads to the formation of a disperse phase in a continuous phase with a dispersity of 0.1 to 5000 nm. Another object of the invention is a method for the in-situ formulation of a pharmaceutical dispersion, with in-line application of the pharmaceutical dispersion.
Claims31
A method for the production of nanodispersions, characterized in that at least two metered partial streams are brought together in such a way that they are subject to thorough mixing caused by turbulence, in which the partial streams have a flow rate in the range from 0.1 to 500 ml/h and the mixed stream has an overall flow rate in the range from 1 ml/h to 500 ml/h, preferably in the range from 10 to 200 ml/h, and during the turbulent mixing there is production of a disperse phase with a dispersity in the range from 0.1 to 5000 nm, preferably in the range from 10 to 1000 nm, and especially in the range from 10 to 200 nm.
Dependencies are inferred from the claim text.