Transgenic animal transformed using green fluorescent protein gene

Abstract

It is intended to provide a novel transgenic animal wherein γ-aminobutyric acid neurons can be visualized in vivo; a method of constructing the same; and a novel model animal of cleft palate. A transgenic animal wherein a green fluorescent protein gene is inserted into the same reading frame as an exon of the glutamate decarboxylase gene, and a model animal with cleft palate comprising the above transgenic animal. In the transgenic animal, the fluorescence of the knockin fluorescent gene at the expression site of the glutamate decarboxylase can be observed and thus the expression site of the gene in vivo can be identified. Moreover, it is useable as a model animal with cleft palate in treating the disease.

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