Mammalian cell membrane proteins;related reagents
AssigneeSchering Corporation
InventorsAlexander B.H. Bakker, Joseph H. Phillips, Lewis L. Lanier
Life of this patent
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Abstract
The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.
Claims20
A substantially pure or recombinant polypeptide:
- a) exhibiting identity over a length of at least about 12 amino acids to the mature polypeptide from SEQ ID NO:
- 2 or 6;
- b) exhibiting identity over a length of at least about 12 amino acids to the mature SEQ ID NO:
- 8 or 10;
- or
- c) exhibiting identity over a length of at least about 12 amino acids to the mature SEQ ID NO:
- 12 or 14.
A nucleic acid which hybridizes under stringent wash conditions of at least 50° C., less than 400 mM salt, and 50% formamide to:
- a) SEQ ID NO:
- 1 or 5;
- b) SEQ ID NO:
- 7 or 9;
- or
- c) SEQ ID NO:
- 11 or 13.
A method of modulating physiology or development of a cell or tissue culture cells comprising contacting said cell with an agonist or antagonist of a DAP12, DAP10, or MDL-1.
Dependencies are inferred from the claim text.