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US 2004/0176855 A1Published application
Decellularized liver for repair of tissue and treatment of organ deficiency
AssigneeACell, Inc.
InventorStephen F. Badylak
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Abstract
The present invention provides a liver-derived devitalized mammalian parenchymatous tissue composition which includes an interstitial structure of connective tissue which can serve as a scaffold for tissue repair or regeneration. The devitalized mammalian parenchymatous tissue composition can further include the basement membrane of the tissue.
Claims26
A scaffold for promoting restoration of a tissue when implanted at an anatomical site in a patient, comprising:
- at least a portion of a liver-derived devitalized mammalian parenchymatous tissue combined with a target mammalian cell population,
- wherein the combined tissue and cell population is sized and shaped for implantation in the patient at the anatomical site remote from the tissue requiring restoration.
A method for promoting restoration of a tissue when implanted at an anatomical site in a patient, comprising:
- providing at least a portion of a liver-derived devitalized mammalian parenchymatous tissue combined with a target mammalian cell population, wherein the combined tissue and cell population is sized and shaped for implantation at the anatomical site in the patient;
- and
- implanting the combined tissue and cell population into a site remote from the tissue requiring restoration.
Dependencies are inferred from the claim text.