Pretreatment method for enhancing tissue adhesion

An apparatus for introducing a closure media to seal a puncture site in a vessel comprising

• a catheter including a closure media introduction port;
• a guidewire lumen extending from a proximal portion to a distal portion of the catheter;
• a static mixer coupled to the closure media introduction port;
• a closure media delivery lumen coupled to the static mixer;
• a closure media advancement port positioned at the distal portion of the catheter;
• and
• an expandable member coupled to the distal portion of the catheter.

A closure device for sealing a puncture in a body vessel comprising

• an elongated body having a proximal end and a distal end sized to be positioned
• within a lumen of the body vessel;
• and
• first and second closure composition precursor lumens within the elongated body,
• the first and second closure composition precursor lumens containing one or more closure composition precursors, the first and second closure composition precursor lumen respectively having first and second entrance ports adjacent the proximal end of the elongated body through which the one or more fluent closure composition precursors can be delivered into the first and second composition precursor lumens respectively, each of the first and second closure composition precursor lumens including an exit port for separately delivering a fluent closure composition precursor adjacent the distal end of the elongated body, the first and second closure composition precursor lumens being connected within the elongated body to cause mixing of the closure composition precursor carried within each lumen.

A closure device for sealing a puncture in a body vessel comprising

• a sealer/dilator for dilating tissue adjacent a vessel puncture, the sealer dilator including a proximal end and a distal end sized to not enter the vessel;
• at least two closure composition precursor lumens within the sealer/dilator having an entrance ports adjacent the proximal end of the sealer/dilator through which one or more fluent closure composition precursors can be delivered into the closure composition precursor lumen, and exit ports adjacent the distal end of the sealer/dilator through which the one or more fluent closure compositions can be delivered outside the vessel adjacent the vessel puncture, the at least two closure composition precursor lumens being connected at a junction within the sealer/dilator;
• a static mixer connected at the junction to cause mixing of closure composition precursor carried within each lumen;
• and
• an exit port adjacent the distal end of the sealer/dilator through which the one or
• more fluent closure composition precursors can be delivered outside the vessel adjacent the vessel puncture.

A closure device for sealing a puncture in a body vessel comprising

• a catheter having a proximal end and a distal end;
• at least two closure composition precursor lumens within the catheter having entrance ports adjacent the proximal end of the catheter through which one or more fluent closure composition precursors can be delivered into the closure composition precursor lumen, and exit ports adjacent the distal end of the catheter through which the one or more fluent closure compositions can be delivered outside the vessel adjacent the vessel puncture, the at least two closure composition precursor lumens being connected at a junction within the catheter;
• and
• a static mixer connected at the junction to cause mixing of closure composition precursor carried within each lumen.