Active needle devices with integrated functionality

An active microneedle device, comprising:

• a hollow non-silicon elongated shaft defining at least one microchannel and having a proximal end and a distal end;
• at least one input port at the proximal end of the elongated shaft and at least one output port at the distal end, the microchannel providing communication between the at least one input port and the at least one output port;
• and
• at least one active component located in the elongated shaft.

An active microneedle array device, comprising:

• a substrate having a substantially planar surface;
• a plurality of hollow non-silicon microneedles on the planar surface of the substrate, each of the microneedles having at least one microchannel that provides communication between at least one input port at a proximal end of each of the microneedles and at least one output port at an opposite distal end that extends beyond an edge of the substrate;
• and
• at least one active component located in one or more of the microneedles.

An active microneedle array device, comprising:

• a plurality of hollow non-silicon microneedles each having at least one microchannel that provides communication between at least one input port at a proximal end of each of the microneedles and at least one output port at an opposite distal end;
• at least one structural support member that interconnects the microneedles;
• and
• at least one active component located in one or more of the microneedles.

An active needle device, comprising:

• a hollow silicon elongated shaft defining at least one channel and having a proximal end and a distal end;
• at least one input port at the proximal end of the elongated shaft and at least one output port at the distal end, the channel providing communication between the at least one input port and the at least one output port;
• and
• at least one active component in the device, the active component comprising a bioluminescence-based biosensor.

An active microneedle device, comprising:

• a hollow silicon elongated shaft defining at least one microchannel and having a proximal end and a distal end;
• at least one input port at the proximal end of the elongated shaft and at least one output port at the distal end, the microchannel providing communication between the at least one input port and the at least one output port;
• and
• at least one active component located in the elongated shaft, the active component comprising a bioluminescence-based biosensor.

An active microneedle array device, comprising:

• a substrate having a substantially planar surface;
• a plurality of hollow silicon microneedles on the planar surface of the substrate, each of the microneedles having at least one microchannel that provides communication between at least one input port at a proximal end of each of the microneedles and at least one output port at an opposite distal end that extends beyond an edge of the substrate;
• and
• at least one active component located in one or more of the microneedles, the active component comprising a bioluminescence-based biosensor.

An active microneedle array device, comprising:

• a plurality of hollow silicon microneedles each having at least one microchannel that provides communication between at least one input port at a proximal end of each of the microneedles and at least one output port at an opposite distal end;
• at least one structural support member that interconnects the microneedles;
• and
• at least one active component located in one or more of the microneedles, the active component comprising a bioluminescence-based biosensor.