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US 2004/0176616 A1Published application
Process for producing optically active compound
AssigneeKanto Kagaku Kabushiki Kaisha
InventorsMasahito Watanabe, Kunihiko Murata, Takao Ikariya
Life of this patent
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Abstract
A highly efficient process is provided for producing an optically active compound having high optical purity by an asymmetric reaction using as a catalyst a transition metal complex having an optically active nitrogen-containing compound as an asymmetric ligand.
Claims9
A process for producing an optically active compound represented by general formula (C)
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- (in the formula, R1 denotes an aromatic monocyclic or aromatic polycyclic hydrocarbon group, which may have a substituent, a saturated or unsaturated aliphatic hydrocarbon group or alicyclic hydrocarbon group, which may have a substituent, a heteromonocyclic or heteropolycyclic group, which may have a substituent, or a hydrogen atom, an alkoxy group, or an amino group;
- R2 and R3 independently denote a hydrogen atom, an aromatic monocyclic or aromatic polycyclic hydrocarbon group, which may have a substituent, a saturated or unsaturated aliphatic hydrocarbon group or alicyclic hydrocarbon group, which may have a substituent, or a heteromonocyclic or heteropolycyclic group, which may have a substituent, and R1 and R2, R1 and R3, or R2 and R3 may be bonded to each other to form a ring;
- R4 denotes a hydrogen atom, an aromatic monocyclic or aromatic polycyclic hydrocarbon group, which may have a substituent, a saturated or unsaturated aliphatic hydrocarbon group or alicyclic hydrocarbon group, which may have a substituent, or a heteromonocyclic or heteropolycyclic group, which may have a substituent;
- R5 and R6 independently denote a hydrogen atom, an aromatic monocyclic or aromatic polycyclic hydrocarbon group, which may have a substituent, a saturated or unsaturated aliphatic hydrocarbon group or alicyclic hydrocarbon group, which may have a substituent, or a straight-chain or branched Cl to C2-0 alkoxy group, and R4 and R5, R4 and R6, or R5 and R6 may be bonded to each other to form a ring;
- X and Y independently denote a single bond, an oxygen atom, a sulfur atom, a nitrogen atom, or a phosphorus atom;
- and m and n are independently 1 or 2;
- when X and/or Y is a single bond, an oxygen atom, or a sulfur atom, m and/or n is 1, and when X and/or Y is a nitrogen atom or a phosphorus atom, m and/or n is 2) by reacting a compound represented by general formula (A)
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- (in the formula, R1, R2, and R3 have the same meaning as above) and a compound represented by general formula (B) [Chem. 2]
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- (in the formula, R4, R5, R6, X, Y, m, and n have the same meaning as above) with an asymmetric metal complex obtained from an optically active nitrogen-containing compound and a complex of a metal of group VIII of the periodic table.
9 more elements
Dependencies are inferred from the claim text.