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US 2004/0176614 A1Published application
Process for the preparation of indole derivatives and intermediates of the process
OwnerAnnemarie Wolleb, Heinz Wollebinventors
Life of this patent
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Abstract
A process for the preparation of compounds of formula 1 wherein R1 is C1-C6alkyl and X is hydrogen, a hydrocarbon radical or a cation, wherein a compound of formula 2 wherein R1 is as defined above and R2 is hydrogen or a hydrocarbon radical, is reduced, the resulting compound of formula 3 is reacted with a compound that introduces the radical of formula —CH2—COOR3, wherein R3 has the meanings given above for R2, and the resulting compound of formula 4 is reduced and optionally hydrolysed.
Claims28
A process for the preparation of a compound of formula
- 39
- wherein R1 is C1-C6alkyl and
- X is hydrogen, a hydrocarbon radical or a cation,
- wherein a compound of formula
- 40
- wherein R1 is as defined above and R2 is hydrogen or a hydrocarbon radical, is reduced, the resulting compound of formula
- 41
- wherein R1 and R2 are as defined above, is reacted with a compound that introduces the radical of formula —CH2—COOR3 wherein R3 has the meanings given above for R2, and the resulting compound of formula
- 42
- is reduced and optionally hydrolysed.
7 more elements
A compound of formula
- 51
- wherein R1 is C1-C6alkyl and
- R2 is hydrogen or a hydrocarbon radical, especially C1-C6alkyl.
A compound of formula
- 59
- wherein R1 is C1-C6alkyl and
- R2 is hydrogen or a hydrocarbon radical, especially C1-C6alkyl.
A compound of formula
- 61
- wherein R1 is C1-C6alkyl, and
- R6 and R7 are hydrogen or hydrocarbon radicals, especially C1-6alkyl.
A compound of formula
- 62
- wherein R1 is C1-C6alkyl and
- Y is bromine, chlorine or iodine, especially bromine.
Dependencies are inferred from the claim text.