Method for preparing n-($g(v)-bromoalkyl)phthalimides
OwnerJean-Philippe Gillet, Chirstophe Ruppininventors
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Abstract
The invention concerns a procedure for preparation of N-(ω-bromoalkyl)phthalimides which consists of reacting potassium phthalimide with an α,ω-dibromoalkane without cosolvent, at a temperature from 50° C. to 130° C. by using a molar ratio of α,ω-dibromoalkane to potassium phthalimide from 3 to 8, of cooling the reaction medium to about 80° C.-85° C., of washing it with water, of decanting, of removing excess α,ω-dibromoalkane from the organic phase under reduced pressure, and then of crystallizing the N-(ω-bromoalkyl)phthalimide with a low boiling point alcohol.
Claims8
Procedure for preparation of N-(ω-bromoalkyl)phthalimides with formula:
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- in which n is a whole number from 2 to 8, and preferably, from 3 to 6, R represents a hydrocarbon radical, straight-chain or branched, with 1 to 4 carbon atoms, a halogen atom such as Cl or Br, or an alkoxy radical such as CH3O—, x is equal to 0, 1, 2, 3 or 4 and when x=2, 3 or 4 the R radicals may be identical or different, which consists of reacting potassium phthalimide (II) with an α,ω-dibromoalkane (III) according to reaction (1):
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- characterized in that it consists of carrying out the condensation reaction (1) of the potassium phthalimide (II) with the α,ω-dibromoalkane (III) without cosolvent, under stirring at a temperature from 50° C. to 130° C., by using a molar ratio of α,ω-dibromoalkane (III) to potassium phthalimide (II) from 3 to 8, then the reaction terminated, the reaction medium is cooled with sufficient amounts of water to solubilize all the kbr formed, it is decanted, then the excess α,ω-dibromoalkane is removed under reduced pressure from the organic phase obtained, and the N-(ω-bromoalkyl)phthalimide obtained is crystallized with a low boiling point alcohol and it is dried under reduced pressure at a temperature equal to 50° C. at most.
Dependencies are inferred from the claim text.