Oxazolidinones having a benzannulated 6- or 7-membered heterocycle

A compound of formula I

• 69
• or a pharmaceutically acceptable salt thereof wherein
• Y is
• a) —NHC(═W)R1,
• b) —O-het, —S-het, or —NH-het;
• X is
• a) —O—,
• b) —S(═O)i—, or
• C) —S(═O)(═NR4)—;
• W is
• a) O, or
• b) S;
• R1 is
• a) H,
• b) C1-8alkyl,
• c) C3-6cycloalkyl,
• d) OC1-4 alkyl,
• e) SC1-4 alkyl,
• f) NH2,
• g) NHC1-6 alkyl, or
• h) N(C1-6 alkyl)2;
• R2 is
• a) H,
• b) halo, or
• c) C1-4 alkyl;
• R3 is
• a) H,
• b) C1-8alkyl,
• c) aryl,
• d) het,
• e) C(═W)R5,
• f) C(═O)OR6, or
• g) S(═O)iR7;
• R4 is
• a) H, or
• b) C1-8alkyl;
• R5 is
• a) H,
• b) aryl,
• c) het,
• d) NR8R9 ,or
• e) C1-8alkyl;
• R6 is
• a) C1-8alkyl,
• b) aryl, or
• c) het;
• R7 is
• a) aryl,
• b) het,
• c) NR8R9, or
• d) C1-8alkyl;
• R8 and R9 are independently
• a) H,
• b) C1-8alkyl, or
• c) aryl;
• wherein >G-E- is >N—C— and Q is a carbon atom, or >G-E is >C=C— and Q is a nitrogen atom;
• aryl is a phenyl radical or an ortho-fused bicyclic carbocyclic radical wherein at least one ring is aromatic;
• het is a C-linked five- (5) or six- (6) membered saturated or unsaturated heterocyclic ring having 1, 2, or 3 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen, which is optionally fused to a benzene ring;
• at each occurrence, alkyl or cycloalkyl is optionally substituted with one or more OR8, halo, aryl, S(═O)iR7, C(═W)R8, OC(═O)C1-6alkyl, or NR8R9;
• at each occurrence, aryl is optionally substituted with one or more halo, OH, CF3, OC1-6alkyl, CN, C1-6 alkyl, S(═O)iR7, C(═W)R8, OC(═O)R8, NHC(═O)R8, or NR8R9;
• at each occurrence, het is optionally substituted with one or more halo, OH, CF3, OC1-6alkyl, CN, C1-6 alkyl, S(═O)iR7, C(═W)R8, OC(═O)R8, NHC(═O)R8, or NR8R9, oxo, or oxime;
• m is 0, 1, 2, 3, or 4;
• n is 0, 1, 2, 3, or 4;
• with the proviso that m and n taken together are 3 or 4;
• and
• i is 0, 1, or 2.