Benzimisazo[4,5-f]isoquinolinone derivatives

A compound of formula I:

• 71
• wherein one of the bond is a double bond, and the other is a single bond;
• Q is N or C;
• R1 is attached to the nitrogen atom having the available valence, and is selected from hydrogen, C1-6alkyl, C2-6alkenyl, C3-6cycloalkyl, aryl-C1-3alkyl, and aryl wherein said alkyl, alkenyl, cycloalkyl, and aryl are optionally substituted with one to three groups independently selected from X;
• R2 is a group selected from R1;
• R3, R4, R6 and R7 are independently selected from hydrogen, X, C2-6alkenyl and C3-6cycloalkyl wherein said alkenyl and cycloalkyl are optionally substituted with one to three groups independently selected from X;
• R5 is selected from hydrogen, C1-6alkyl, C2-6alkenyl, Cy, and Cy-C1-3alkyl, wherein said alkyl, alkenyl, and Cy are optionally substituted with one to three groups independently selected from X;
• Cy is selected from cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• X is selected from:
• (a) halo,
• (b) CN,
• (c) ORa,
• (d) C1-6perfluoroalkyl,
• (e) C(O)Ra,
• (f) C(O)ORa,
• (g) C(O)NRbRc,
• (h) NRbRc,
• (i) NHRbNHRb,
• (j) NHC(O)Ra,
• (k) NHC(O)ORa,
• (l) phenyl wherein phenyl is optionally substituted with one to three groups independently selected from Rx,
• (m) C1-6alkyl optionally substituted with OH, C3-7cycloalkyl, phenyl, or heterocyclyl, wherein phenyl is optionally substituted with one to three groups independently selected from Rx, and wherein said heterocyclyl is optionally substituted with one to three groups independently selected from Ry,
• (n) heterocyclyl wherein said heterocyclyl is optionally substituted with one to three groups independently selected from Ry,
• (o) S(O)nRa, wherein n is 0, 1 or 2 and
• (p) SO2NHRa;
• Ra, Rb and Rc are independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, Cy and Cy-C1-3alkyl, wherein Cy is optionally substituted with one to three groups selected from Ry;
• or
• Rb and Rc together with the atom(s) to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and N—Re;
• Re is selected from hydrogen, C1-6alkyl, Cy and Cy-C1-3alkyl;
• Rx is selected from halo, phenyl, CN, NO2, OH, OC1-6alkyl, C1-6alkyl, NH2, NHC1-6alkyl, N(C1-6alkyl)2, C(O)C1-6alkyl, C(O)OC1-6alkyl, C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)2, NHC(O)Cl1-6alkyl;
• Ry is a group selected from Rx, oxo, C1-6alkyl substituted with C3-7cycloalkyl, and C(O)OCH2-phenyl;
• or a pharmaceutically acceptable salt thereof.