Back to results
US 2004/0176598 A1Published application
Azaindole derivatives as inhibitors of p38 kinase
AssigneeScios, Inc.
InventorSundeep Dugar
Life of this patent
Estimating the term…
Abstract
The invention is directed to methods to inhibit p38 kinase, preferably p38-α using compounds which are azaindoles wherein the azaindoles are coupled through a piperidine or piperazine type linker to another cyclic moiety.
Claims41
A compound of the formula:
- 93
- and the pharmaceutically acceptable salts thereof, wherein
- represents a single or double bond;
- each Z2 is independently CR1 or C(R1)2 wherein each R1 is independently hydrogen or noninterfering substituent;
- Z3 is NR7, O, or S;
- R7 is hydrogen or a non-interfering substituent;
- each of Z4 and Z5 is independently N or CR1 wherein R1 is as defined above and wherein at least one of Z4 and Z5 is N;
- each R3 is independently a noninterfering substituent;
- n is 0-3;
- each of L1 and L2 is a linker;
- each R4 is independently a noninterfering substituent;
- m is 0-4;
- Z1 is CR5 or N wherein R5 is hydrogen or a noninterfering substituent;
- each of 1 and k is an integer from 0-2 wherein the sum of 1 and k is 0-3;
- A is a cyclic group substituted with 0-5 noninterfering substituents, wherein two said noninterfering substituents can form a fused ring.
12 more elements
Dependencies are inferred from the claim text.