Nitrogenous heterocyclic compounds

A nitrogen-containing heterocyclic compound of the formula:

• 55
• wherein
• R is a member selected from the group consisting of:
• (a) phenyl, which is independently substituted with 0-2 R1 substituents;
• (b) naphthyl, which is independently substituted with 0-2 R1 substituents;
• (c) a monocyclic or fused bicyclic heterocyclic ring system having from 5 to 10 ring atoms, wherein 1-4 ring atoms of the ring system are selected from the group consisting of N, O and S, and wherein the ring system may be substituted with 0-2 R1 substituents;
• and
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• R1 is a member selected from the group consisting of:
• halo, C14alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C0-4alkylC3-8cycloalkyl, —CN, —NO2, —(CH2)mNR2R3, SO2NR2R3, SO2R2, CF3, OR2, phenyl, naphthyl, and a 5-6 membered aromatic heterocyclic system containing from 1-4 heteroatoms selected from N, O and S, wherein from 1-4 hydrogen atoms on the aromatic heterocyclic system may be independently replaced with a member selected from the group consisting of halo, —C1-C4-alkyl, —CN, —C1-4alkyl, —C2-6alkenyl, —C2-6alkynyl, —C3-8cycloalkyl, —C0-4alkylC3-8cycloalkyl and —NO2;
• R2 and R3 are independently selected from the group consisting of:
• H, C1-4alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C0-4alkylC3-8cycloalkyl, C0-4alkylphenyl, C0-4alkylnaphthyl, C0-4alkylindolyl, and C0-4alkylisoquinolyl, wherein from 1-4 hydrogen atoms on the ring atoms of the phenyl, naphthyl, indolyl, or isoquinolyl moieties may be independently replaced with a member selected from the group consisting of halo, C1-4alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C0-4alkylC3-8cycloalkyl, —CN, and —NO2;
• m is an integer of 0-2;
• R4 and R6 are each independently a member selected from the group consisting of:
• —O—CH3, —O(—CH2)—CH3, —O—CH2—CH═CH2, —O—CH2—C4CH and —O(—CH2)n—R5;
• n is 2 or 3;
• R5 is a member selected from the group consisting of:
• —OH, —O—CH3, —O—CH2—CH3, —NH2, —N(—CH3)2, —NH(—CH2-phenyl), —NH(-Phenyl), —CN
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• and all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives thereof.