Immunoassays for specific determination of SCCA isoforms
OwnerEva Rojer, Olle Nilssoninventors
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Abstract
The present invention relates to monoclonal antibodies capable of distinguishing squamous cell cancer antigens, SCCA, in either free or complex bound forms, preferably antigens SCCA1 and SCCA2, as well as hybridomas recognizing such antibodies, method for diagnosing SCC, as well as diagnostic kits for detecting SCCAs.
Claims28
A monoclonal antibody capable of distinguishing between free and total SCCA.
A method for diagnosing cancer calculating the ratio between free SCCA1 and total SCCA1 or complex-bound SCCA1.
A method for diagnosing cancer calculating the ratio between free SCCA1 and total SCCA.
A monoclonal antibody according to claim 10, where the antibody has been produced by hybridoma.
A method for diagnosing cancer or detection of recurrent cancer disease using immunoassays according to claim 13.
A method for diagnosing cancer or recurrent cancer disease calculating the ratio between free SCCA2 and total SCCA.
A method for diagnosing squamous cancer or recurrent cancer disease calculating the ratio between free SCCA2 and total SCCA1, complex bound SCCA1 and/or free SCCA1.
A kit for diagnosing cancer or detecting recurrent cancer disease, whereby the kit comprises monoclonal antibodies capable of distinguishing between free and total SCCA.
A kit for diagnosing cancer or detecting recurrent cancer disease, whereby the kit comprises monoclonal antibodies capable of distinguishing between free and total SCCA1.
A kit for diagnosing cancer or detecting recurrent cancer disease, whereby the kit comprises monoclonal antibodies capable of distinguishing between free and total SCCA2.
A kit for diagnosing cancer or detecting recurrent cancer disease, whereby the kit comprises hybridomas recognizing monoclonal antibodies capable of distinguishing between free and total SCCA.
A kit for diagnosing cancer or detecting recurrent cancer disease, whereby the kit comprises hybridomas recognizing monoclonal antibodies capable of distinguishing between free and total SCCA1.
A kit for diagnosing cancer or detecting recurrent cancer disease, whereby the kit comprises hybridomas recognizing monoclonal antibodies capable of distinguishing between free and total SCCA2.
Dependencies are inferred from the claim text.