Transporter genes
AssigneeChugai Seiyaku Kabushiki Kaisha, a Japan corporation
InventorsJun-Ichi Nezu, Asuka Oku
Life of this patent
Estimating the term…
Abstract
Novel genes significantly homologous to organic cation transporters OCT1 and OCT2 have been successfully isolated by screening a fetal gene library by random sequencing. Proteins encoded by these genes function as transporters of various organic cations.
Claims28
A substantially pure polypeptide comprising an amino acid sequence at least 70% identical to any one of SEQ ID NOs:1, 3, 22, or 27, wherein the polypeptide is a transporter of an organic cation.
A substantially pure polypeptide comprising the sequence of any one of SEQ ID NOs:1, 3, 22, or 27.
A substantially pure polypeptide comprising the amino acid sequence of any one of SEQ ID NOs:1, 3, 22, or 27, with up to 30 conservative amino acid substitutions, wherein the polypeptide is a transporter of an organic cation.
A substantially pure polypeptide encoded by a nucleic acid that hybridizes under stringent conditions to a probe the sequence of which consists of any one of SEQ ID NOs:2, 4, 23, or 28, wherein the polypeptide is a transporter of an organic cation.
An isolated nucleic acid comprising a strand that hybridizes under stringent conditions to a single stranded probe, the sequence of which consists of any one of SEQ ID NOs:2, 4, 23, or 28, or the complement of any one of SEQ ID NOs:2, 4, 23, or 28.
Dependencies are inferred from the claim text.