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US 2004/0176471 A1Published application
Novel chalcone derivatives and pharmaceutical compositions comprising the same
AssigneeKaohsiung Medical University
InventorsChun-Nan Lin, Jih-Pyang Wang
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Abstract
Disclosed herein are novel chalcone derivatives of formulas (I), (II) and (III): 1 wherein each of the substituents is given the definition as set forth in the Specification and Claims. These compounds are demonstrated to have anti-inflammatory activities and thus can be used in the treatment of an inflammatory disorder in a subject.
Claims26
A compound of formula (I):
- 28
- or a pharmaceutically acceptable salt or solvate thereof,
- wherein
- R2′ and R5′ are the same and represent OR, where R is H or a C1-6 alkyl group;
- or R2′ is OH and R5′ is propoxy;
- R3 represents H or Cl;
- and
- R4 represents OH, Cl or Br;
- with the proviso that when R3 is H, R4 cannot be Cl.
6 more elements
A compound of formula (II):
- 29
- or a pharmaceutically acceptable salt thereof,
- wherein both R2′ and R5′ are OH.
A compound of formula (III):
- 30
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.