Substituted amino dicarboxylic acid derivatives

A compound of the general formula (I)

• 82
• where
• V is missing or represents O, NR4, NR4CONR4, NR4CO, NR4SO2, COO, CONR4 or S(O)o,
• where
• R4 independently of any other radical R4 optionally present represents hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, aryl having 6 to 10 carbon atoms or arylalkyl having 7 to 18 carbon atoms, where the aryl radical for its part may be mono- or polysubstituted by halogen, alkyl, alkoxy having up to 6 carbon atoms,
• o represents 0, 1 or 2,
• Q is missing or represents straight-chain or branched alkylene, straight-chain or branched alkenediyl or straight-chain or branched alkynediyl having in each case up to 12 carbon atoms, which radicals may in each case comprise one or more groups selected from the group consisting of O, S(O)p, NR5, CO, NR5SO2 or CONR5 and which may be mono- or polysubstituted by halogen, hydroxyl or alkoxy having up to 4 carbon atoms, where optionally any two atoms of the above chain may be attached to one another forming a three- to eight-membered ring,
• where
• R5 represents hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms which may be substituted by halogen or alkoxy having up to 4 carbon atoms,
• p represents 0, 1 or 2,
• Y represents hydrogen, NR8R9, aryl having 6 to 10 carbon atoms, an aromatic or saturated heterocycle having 1 to 9 carbon atoms and up to 3 heteroatoms from the group consisting of S, N and O or straight-chain or branched cycloalkyl having 3 to 8 carbon atoms, which may also be attached via N,
• where the cyclic radicals may in each case be mono- to trisubstituted by straight-chain or branched alkyl, straight-chain or branched alkenyl, straight-chain or branched alkynyl, straight-chain or branched alkoxy, straight-chain or branched haloalkyl, straight-chain or branched haloalkoxy having in each case up to 8 carbon atoms, straight-chain or branched cycloalkyl having 3 to 8 carbon atoms, halogen, hydroxyl, CN, SR6, NO2, NR8R9, NR7COR10, NR7CONR7R10 or CONR11R12,
• where
• R6 represents hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms, straight-chain or branched haloalkyl having up to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms,
• R7 independently of any other radical R7 optionally present represents hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms,
• R8, R9, R11 and R12 independently of one another represent hydrogen, straight-chain or branched alkyl, straight-chain or branched alkenyl having up to 8 carbon atoms, aryl having 6 to 10 carbon atoms, an aromatic heterocycle having 1 to 9 carbon atoms and up to 3 heteroatoms from the group consisting of S, N and O, arylalkyl having 8 to 18 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or a radical of the formula SO2R13,
• where the aryl radical for its part may be mono- or polysubstituted by halogen, hydroxyl, CN, NO2, NH2, NHCOR7, alkyl, alkoxy, haloalkyl or haloalkoxy having up to 6 carbon atoms,
• where
• R13 represents straight-chain or branched alkyl having up to 4 carbon atoms or aryl having 6 to 10 carbon atoms, where the aryl radical for its part may be mono- or polysubstituted by halogen, CN, NO2, alkyl, alkoxy, haloalkyl or haloalkoxy having up to 6 carbon atoms,
• or two substituents selected from R8 and R9 or R11 and R12 may be attached to one another forming a five- or six-membered ring which may contain O or N,
• R10 represents hydrogen, straight-chain or branched alkyl having up to 12 carbon atoms, straight-chain or branched alkenyl having up to 12 carbon atoms, aryl having 6 to 10 carbon atoms, an aromatic heterocycle having 1 to 9 carbon atoms and up to 3 heteroatoms from the group consisting of S, N and O or cycloalkyl having 3 to 8 carbon atoms, which may optionally furthermore be substituted by halogen, hydroxyl, CN, NO2, NH2, NHCOR7, alkyl, alkoxy, haloalkyl or haloalkoxy having up to 6 carbon atoms;
• and/or the cyclic radicals may in each case be mono- to trisubstituted by aryl having 6 to 10 carbon atoms, a saturated carbocycle having 6 to 10 carbon atoms, an aromatic or saturated heterocycle having 1 to 9 carbon atoms and up to 3 heteroatoms from the group consisting of S, N and O, which may also be attached via N,
• which may be attached directly or via a group selected from the group consisting of O, S, SO, SO2, NR7, SO2NR7, CONR7, straight-chain or branched alkylene, straight-chain or branched alkenediyl, straight-chain or branched alkyloxy, straight-chain or branched oxyalkyloxy, straight-chain or branched sulfonylalkyl, straight-chain or branched thioalkyl having in each case up to 8 carbon atoms and which may be mono- to trisubstituted by straight-chain or branched alkyl, straight-chain or branched alkoxy, straight-chain or branched alkoxyalkoxy, straight-chain or branched haloalkyl, straight-chain or branched haloalkoxy, carbonylalkyl or straight-chain or branched alkenyl having in each case up to 6 carbon atoms, halogen, SR6, CN, NO2, NR8R9, CONR15R16 or NR14COR17,
• where
• R14 represents hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms,
• R15, R16 independently of one another represent hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, aryl having 6 to 10 carbon atoms or a radical of the formula SO2R18, where the aryl radical for its part may be mono- or polysubstituted by halogen, hydroxyl, CN, NO2, NH2, NHCOR7, alkyl, alkoxy, haloalkyl or haloalkoxy having up to 6 carbon atoms,
• where
• R18 represents straight-chain or branched alkyl having up to 4 carbon atoms or aryl having 6 to 10 carbon atoms, where the aryl radical for its part may be mono- or polysubstituted by halogen, hydroxyl, CN, NO2, NH2, NHCOR7, alkyl, alkoxy, haloalkyl or haloalkoxy having up to 6 carbon atoms,
• and
• R17 independently of one another represents hydrogen, straight-chain or branched alkyl having up to 12 carbon atoms, straight-chain or branched alkenyl having up to 12 carbon atoms, aryl having 6 to 10 carbon atoms, an aromatic heterocycle having 1 to 9 carbon atoms and up to 3 heteroatoms from the group consisting of S, N and O or cycloalkyl having 3 to 8 carbon atoms, which may optionally furthermore be substituted by halogen, hydroxyl, CN, NO2, NH2, NHCOR7, alkyl, alkoxy, haloalkyl or haloalkoxy having up to 6 carbon atoms;
• and/or the cyclic radicals may be fused with an aromatic or saturated carbocycle having 1 to 10 carbon atoms or an aromatic or saturated heterocycle having 1 to 9 carbon atoms and up to 3 heteroatoms from the group consisting of S, N and O,
• R3 represents SR17, SO2R17, aryl having 6 to 10 carbon atoms which is optionally substituted by one or two halogen atoms, heteroaryl having 1 to 9 carbon atoms and up to 3 heteroatoms from the group consisting of S, N and O, cycloalkyl having 3 to 8 carbon atoms, hydroxyl, haloalkoxy having up to 6 carbon atoms, cycloalkoxy having up to 14 carbon atoms, CONH2, CONR17R17, SO2NH2, SO2NR17R17, alkoxyalkoxy having up to 12 carbon atoms, alkoxyalkyl having up to 12 carbon atoms, cycloalkylalkyl having up to 12 carbon atoms, NHCOOR17 NR17COOR17, NHCOR17, NHSO2R17 NR17SOR17, NHCONH2, NR17CONR17R17, OCONR17R17, OSO2R17, C2-12-alkenyl or C2-12-alkynyl, where in addition to one of the abovementioned radicals a radical from the group consisting of hydrogen, halogen, straight-chain or branched alkyl, straight-chain or branched haloalkyl, straight-chain or branched alkoxy, or alkoxycarbonyl having in each case up to 4 carbon atoms, CN, NO2 and NR19R20 may be included;
• where
• R19 and R20 independently of one another represent hydrogen, straight-chain or branched alkyl having up to 4 carbon atoms or cycloalkyl having 3 to 8 carbon atoms,
• m represents an integer from 1 to 4,
• W represents straight-chain or branched alkylene having up to 6 carbon atoms or straight-chain or branched alkenediyl having up to 6 carbon atoms which may in each case contain a group selected from the group consisting of O, S(O)q, NR21, CO or CONR21, or represents CO, NHCO or OCO,
• where
• q represents 0, 1 or 2,
• R21 represents hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms,
• U represents straight-chain or branched alkyl having up to 4 carbon atoms,
• A represents aryl having 6 to 10 carbon atoms or an aromatic heterocycle having 1 to 9 carbon atoms and up to 3 heteroatoms from the group consisting of S, N and O,
• which may optionally be mono- to trisubstituted by halogen, straight-chain or branched alkyl, straight-chain or branched haloalkyl, straight-chain or branched alkoxy, haloalkoxy or alkoxycarbonyl having up to 4 carbon atoms, CN, NO2 or NR22R23,
• where
• R22 and R23 in each case independently of one another represent hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms, carbonylalkyl or sulfonylalkyl,
• R2 represents tetrazolyl, COOR24 or CONR25R26,
• where
• R24 [lacuna] hydrogen, alkyl having 1 to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms
• R25 and R26 in each case independently of one another represent hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or a radical of the formula SO2R27,
• where
• R27 represents straight-chain or branched alkyl having up to 4 carbon atoms or aryl having 6 to 10 carbon atoms, where the aryl radical for its part may be mono- or polysubstituted by halogen, CN, NO2, alkyl, alkoxy, haloalkyl or haloalkoxy having up to 6 carbon atoms,
• or R25 and R26 together form a five- or six-membered ring which may contain N or O,
• X represents straight-chain or branched alkylene having up to 12 carbon atoms or straight-chain or branched alkenediyl having up to 12 carbon atoms, which may in each case contain one to three groups selected from the group consisting of O, S(O)r, NR28, CO or CONR29, aryl and aryloxy having 6 to 10 carbon atoms, where the aryl radical for its part may be mono- or polysubstituted by halogen, CN, NO2, alkyl, alkoxy, haloalkyl or haloalkoxy having up to 6 carbon atoms, where optionally any two atoms of the abovementioned chains are attached to one another via an alkyl chain forming a three- to eight-membered ring,
• where
• r represents 0, 1 or 2,
• R28 represents hydrogen, alkyl having 1 to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms,
• R29 represents hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms,
• n represents 1 or 2;
• R1 represents tetrazolyl, COOR30 or CONR31R32,
• where
• R30 [lacuna] hydrogen, alkyl having 1 to 8 carbon atoms or cycloalkyl having 3 to 8 carbon atoms
• R31 and R32 in each case independently of one another represent hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or a radical of the formula SO2R33,
• where
• R33 represents straight-chain or branched alkyl having up to 4 carbon atoms or aryl having 6 to 10 carbon atoms, where the aryl radical for its part may be mono- or polysubstituted by halogen, CN, NO2, alkyl, alkoxy, haloalkyl or haloalkoxy having up to 6 carbon atoms,
• and its stereoisomers and salts.