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US 2004/0176434 A1Published application
Methods for treating inflammatory conditions or inhibiting JNK
AssigneeSignal Pharmaceuticals, LLC
InventorsBrydon L. Bennett, Shripad S. Bhagwat, Anthony M. Manning, Brion W. Murray, Eoin C. O'Leary, Yoshitaka Satoh
Life of this patent
Estimating the term…
Abstract
This invention generally relates to methods for treating or preventing an inflammatory disease or disorder comprising administering to a patient in need thereof an effective amount of a Pyrazoloanthrone Derivative having the following structure: 1 or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.
Claims15
A method for the treating or preventing an inflammatory condition, comprising administering to a patient in need thereof an effective amount of a compound having the structure:
- 66
- or a pharmaceutically acceptable salt thereof,
- wherein
- R1 and R2 are absent or present and independently represent alkyl, halogen, nitro, trifluoromethyl, sulfonyl, carboxyl, alkoxycarbonyl, alkoxy, aryl, aryloxy, arylalkyloxy, arylalkyl, cycloalkylalkyloxy, cycloalkyloxy, alkoxyalkyl, alkoxyalkoxy, aminoalkoxy, mono- or di-alkylaminoalkoxy, or a group represented by formula (a), (b), (c) or (d).
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- R3 and R4 taken together represent alkylidene or a heteroatom-containing alkylidene, or R3 and R4 are the same or different and independently represent hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, cycloalkylalkyl, aryloxyalkyl, alkoxyalkyl, alkoxyamino, or alkoxy(mono- or di-alkylamino);
- and
- R5 represents hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, cycloalkylalkyl, alkoxy, amino, mono- or di-alkylamino, arylamino, arylalkylamino, cycloalkylamino, or cycloalkylalkylamino.
5 more elements
Dependencies are inferred from the claim text.