4-hydroxpiperdine derivative with analgetic activity

A compound or its salt selected from

• 1-[2-(4-cyanophenyl)ethyl]-4-(4-nitrophenoxymethyl)piperidin-4-ol;
• 1-[2-(4-cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol;
• 4-(4-carbamoylphenoxymethyl)-l -[2-(4-cyanophenyl)ethyl]piperidin-4-ol;
• methyl 4-{1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethoxy}benzoate;
• 4-{l-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethoxy}benzoic acid;
• 1-[2-(4-cyanophenyl)ethyl]-4-(4-hydroxymethylphenoxylmethyl)piperidin-4-ol;
• methyl 4-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}methylamino)benzoate;
• 4-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}methylamino)benzoic acid;
• 4-({1-[2-(3-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}methylamino)benzoic acid;
• 4-({1-[2-(2-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}methylamino)benzoic acid;
• 3-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}methylamino)benzoic acid;
• 2-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}methylamino)benzoic acid;
• 4-[2-(4-hydroxy-4-{[methyl(4-nitrophenyl)amino]methyl}piperidin-1-yl)ethyl]benzonitrile;
• 4-{2-[4-hydroxy-4-({methyl[-4-(1H-tetrazol-5-yl)phenyl]amino}methyl)piperidin-1-yl]ethyl}benzonitrile;
• 4-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}amino)benzoic acid;
• 4-({4-hydroxy-1-[2-(4-methanesulfonylphenyl)ethyl]piperidin-4-ylmethyl}methylamino)benzoic acid;
• and
• 4-[(4-hydroxy-1-phenethylpiperidin-4-ylmethyl)methylamino]benzoic acid.