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US 2004/0176399 A1Published application
A2B adenosine receptor antagonists
AssigneeCV Therapeutics, Inc.
InventorsElfatih Elzein, Rao Kalla, Tim Marquart, Jeff Zablocki, Xiaofen Li
Life of this patent
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Abstract
Disclosed are processes for the synthesis of novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
Claims55
A process for the preparation of a compound of Formula I:
- 67
- wherein:
- R1 and R2 are independently optionally substituted alkyl;
- X is optionally substituted arylene or optionally substituted heteroarylene;
- Y is a covalent bond or lower alkylene;
- and
- Z is optionally substituted monocyclic aryl or optionally substituted monocyclic heteroaryl;
- comprising;
- cyclizing a compound of the formula (3):
- 68
- wherein R1, R2, X, Y, and Z are as defined above.
8 more elements
An intermediate of the formula:
- 94
- wherein:
- R1 and R2 are independently chosen from methyl, ethyl, n-propyl, 2-methylpropyl, and cyclopropylmethyl.
An intermediate of the formula:
- 96
- wherein R1 is n-propyl or cyclopropylmethyl.
An intermediate of the formula:
- 98
- wherein R2 is methyl or ethyl.
An intermediate of the formula:
- 100
- wherein R1 and R2 are independently chosen from methyl, ethyl, n-propyl, 2-methylpropyl, and cyclopropylmethyl.
Dependencies are inferred from the claim text.