(Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds

A compound of the formula (I):

• 781
• or a pharmaceutically acceptable salt or hydrate thereof,
• wherein FusedHet is
• 782
• R1 is H,
• —C1-6alkyl,
• —C(O)(C1-6alkyl),
• —C(O)—C1-6alkyl-aryl,
• —C0-4alkyl-aryl,
• —C0-4alkyl-indanyl,
• —C0-4alkyl-imidazolyl,
• —C0-4alkyl-thiazolyl,
• —C0-4alkyl-pyrazolyl,
• —C0-4alkyl-oxadiazolyl,
• —C0-4alkyl-C3-6cycloalkyl,
• —C0-4alkyl-C1-4alkoxy,
• —C1-4alkyl-N(C0-4alkyl)(—C0-4alkyl),
• —C1-4alkyl-N(—C0-4alkyl)-CO—C1-4alkoxy,
• —C1-4alkyl-piperadinyl,
• —C0-4alkyl-triazolyl,
• —C1-4alkyl-imidazothiazolyl,
• —C1-4alkyl-benzimidazolyl,
• —C1-4alkyl-benzothiazolyl,
• —C1-4alkyl-benzotetrahydrofuranyl,
• —C1-4alkyl-benzodioxolyl,
• —C1-4alkyl-(heterocycloC4O2alkyl),
• —C1-4alkyl-(heterocycloC5O1alkyl),
• —C1-4alkyl-tetrahydrofuran, or
• —C1-4alkyl-oxetanyl;
• R11 is H or —C1-6alkyl;
• or R1 and R11, together with the N to which they are attached, form a morpholinyl;
• R2, R21, R22 each independently is H, halogen, or —C1-4alkyl;
• R3 is H,
• —C1-4alkyl,
• —C3-6cycloalkyl,
• —C1-4alkyl-aryl,
• —C1-4alkyl-azetidinyl,
• —C1-4alkyl-azetidinyl-CO—C0-4alkyl-N(C0-4alkyl)(C0-4alkyl),
• —C1-4alkyl-pyrrolidinyl,
• —C1-4alkyl-piperidinyl,
• —C1-4alkyl-morpholinyl,
• —C0-4alkyl-N(C0-4alkyl)(C0-4alkyl),
• —C0-4alkyl-N(C0-4alkyl)(C0-4alkyl-C1-4alkoxy),
• —C0-4alkyl-N(C0-4alkyl-C1-4alkoxy)(C0-4alkyl-C1-4alkoxy),
• —C1-4alkyl-N(C0-4alkyl)(C1-4alkyl)-aryl,
• —C1-4alkyl-N(C0-4alkyl)-C1-4alkyl-tetrahydrofuranyl,
• —C1-4alkyl-N(C0-4alkyl)-C1-4alkyl-azetidinyl,
• —C1-4alkyl-N(C0-4alkyl)-C1-4alkyl-N(C0-4alkyl)(C0-4alkyl),
• —C1-4alkyl-N(C0-4alkyl)-C1-4alkyl-N(C0-4alkyl)-C0-4alkyl-SO2C1-4alkyl),
• —CO—N(C0-4alkyl)-C1-4alkyl-aryl,
• —CO—N(C0-4alkyl)-C1-4alkyl-N(C0-4alkyl)(C0-4alkyl),
• —C0-4alkyl-CO—C0-4alkyl,
• —C0-4alkyl-CO—C0-4alkoxy,
• —C0-4alkyl-CO—N(C0-4alkyl)-C1-4alkyl-C1-4alkoxy,
• —C0-4alkyl-CO—N(C0-4alkyl)-C1-4alkyl-aryl,
• —C0-4alkyl-CO-piperidinyl,
• —C1-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C0-4alkyl-N(C0-4alkyl)(C0-4alkyl),
• —C0-4alkyl-CO—C0-4alkyl-N(C0-4alkyl)(C0-4alkyl),
• —O—C1-4alkyl-aryl,
• —C1-4alkyl-O—C1-4alkyl,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C0-4alkyl,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C0-4alkoxy,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C0-4alkyl-aryl,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C0-4alkyl(aryl)2,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C0-4alkyl-pyrrolyl,
• —C0-4alkyl-N(C0-4alkyl-C0-4alkyl-CO—C0-4alkyl-pyrrolidinyl,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C0-4alkyl-azetidinyl,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C2-4alkenyl-pyrrolidinyl,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C0-4alkyl-thiophenyl,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C2-4alkenyl-thiophenyl,
• —C0-4alkyl-N(C0-4alkyl-C0-4alkyl-CO—S—C1-4alkyl-aryl,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—C3-6cyclolkyl,
• —C0-4alkyl-N(C0-4alkyl)-C0-4alkyl-CO—O—C1-4alkyl-aryl,
• —C0-4alkyl-CO—N(C0-4alkyl)-C0-4alkyl-C1-4alkoxy,
• —C1-4alkyl-N(C0-4alkyl)(—SO2C1-4alkyl),
• —C0-4alkyl-N(C0-4alkyl)-C1-4alkyl-SO2C1-4alkyl,
• —C0-4alkyl-S—C1-4alkyl-aryl,
• —C1-4alkyl-PO(C1-4alkoxy)(C1-4alkoxy),
• —C1-4alkyl-azetidinyl-CO—N(C0-4alkyl)(C0-4alkyl),
• —C1-4alkyl-(heterocycloC4N1O1alkyl),
• —C0-4alkyl-CO-(heterocycloC5N1alkyl),
• —C0-4alkyl-CO—N(C0-4alkyl)(heterocycloC5N1alkyl),
• —C1-4alkyl-(heterocycloC4N2alkyl)-C1-4alkyl,
• —C1-4alkyl-(heterocycloC4N2alkyl)-CO—C0-4alkoxy,
• —C1-4alkyl-(heterocycloC4N2alkyl)-C1-4alkyl-N(C0-4alkyl)(C0-4alkyl),
• —C1-4alkyl-(heterobicycloC5N2alkyl)-C1-4alkyl, or
• —C1-4alkyl-NH-(heterobicycloC7N1alkyl);
• and
• R4 is —C1-6alkyl;
• wherein any of the above aryl, hetaryl, cycloalkyl, or heterocycloalkyl optionally is substituted with 1-4 substituents, each substituent independently is halogen, NO2, —CN, —C1-4alkyl, —C0-4alkoxy, —S—C1-4alkyl, or —C0-4alkyl-(CO)—C0-4alkoxy;
• and any of the above alkyl optionally is substituted with 14 substituents, each substituent independently is halogen, —N3, —CN, —COOH, or C0-4alkoxy.