Compositions of a cyclooxygenase-2 selective inhibitor and an amphetamine for the treatment of reduced blood flow to the central nervous system
AssigneePharmacia Corporation
InventorDiane T. Stephenson
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Abstract
The present invention provides compositions and methods for the treatment of reduced blood flow to the central nervous system in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition comprising the administration to a subject of an amphetamine in combination with a cyclooxygenase-2 selective inhibitor.
Claims31
A method to treat a reduction in blood flow to the central nervous system, the method comprising:
- (a) diagnosing a subject in need of treatment for a reduction in blood flow to the central nervous system;
- and
- (b) administering to the subject a cyclooxygenase-2 selective inhibitor or an isomer, a pharmaceutically acceptable salt, ester, or prodrug of a cyclooxygenase-2 selective inhibitor and an amphetamine or an isomer, a pharmaceutically acceptable salt, ester, or prodrug of an amphetamine.
A method to treat a reduction in blood flow to the central nervous system, the method comprising:
- (a) diagnosing a subject in need of treatment for a reduction in blood flow to the central nervous system;
- and
- (b) administering to the subject a cyclooxygenase-2 selective inhibitor that is a chromene compound, the chromene compound comprising a benzothiopyran, a dihydroquinoline or a dihydronaphthalene or an isomer, a pharmaceutically acceptable salt, ester, or prodrug of the chromene compound and an amphetamine or an isomer, a pharmaceutically acceptable salt, ester, or prodrug of an amphetamine.
A method to treat a reduction in blood flow to the central nervous system, the method comprising:
- (a) diagnosing a subject in need of treatment for a reduction in blood flow to the central nervous system;
- and
- (b) administering to the subject a cyclooxygenase-2 selective inhibitor that is a tricyclic compound, the tricyclic compound comprising a benzenesulfonamide or methylsulfonylbenzene or an isomer, a pharmaceutically acceptable salt, ester, or prodrug of the tricyclic compound and an amphetamine or an isomer, a pharmaceutically acceptable salt, ester, or prodrug of an amphetamine.
A method to treat a reduction in blood flow to the central nervous system, the method comprising:
- (a) diagnosing a subject in need of treatment for a reduction in blood flow to the central nervous system;
- and
- (b) administering to the subject a cyclooxygenase-2 selective inhibitor that is a phenyl acetic acid compound or an isomer, a pharmaceutically acceptable salt, ester, or prodrug of the phenyl acetic acid compound and an amphetamine or an isomer, a pharmaceutically acceptable salt, ester, or prodrug of an amphetamine.
Dependencies are inferred from the claim text.