Novel pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them

A compound of formula (I)

• 249
• wherein A represents A1 or A2
• 250
• R is unsubstituted or at least monosubstituted C1-C10-alkyl, aryl, aryl-(C1-C10-alkyl)-, heteroaryl, heteroaryl-(C1-C10-alkyl)-, heterocyclyl, heterocyclyl-(C1-C10-alkyl)-, C3-C10-cycloalkyl, polycycloalkyl, C2-C10-alkenyl or C2-C10-alkinyl,
• where the substituents are chosen from halogen, —CN, C1-C10-alkyl, —NO2, —OR1, —C(O)OR1, —O—C(O)R1, —NR1R2, —NHC(O)R1, —C(O)NR1R2, —SR1, —S(O)R1-SO2R1, —NHSO2R1, —SO2NR1R2, —C(S)NR1R2, —NHC(S)R1, —O—SO2R1, —SO2—O—R1, oxo, —C(O)R1, —C(NH)NH2, heterocyclyl, C3-C10-cycloalkyl, aryl-(C1-C6-alkyl)-, aryl, heteroaryl, trifluoromethyl, trifluoromethylsulfanyl and trifluoromethoxy,
• and aryl, heterocyclyl and heteroaryl may in turn be at least monosubstituted with C1-C6-alkyl, C1-C6-alkoxy, halogen, trifluoromethyl, trifluoromethoxy or OH;
• Ar is unsubstituted or at least monosubstituted aryl or heteroaryl;
• where the substituents are chosen from halogen, —CN, NO2, C1-C10-alkyl, —OR1, —C(O)OR1, —O—C(O)R1, —NR1R2, —NHC(O)R1, —C(O)NR1R2, —NHC(S)R1, —C(S)NR1R2, —SR1, —S(O)R1, —SO2R1, —NHSO2R1, —SO2NR1R2, —O—SO2R1, —SO2—O—R1, aryl, heteroaryl, aryl-(C1-C6-alkyl)-, formyl, trifluoromethyl and trifluoromethoxy,
• and aryl and heteroaryl may in turn be at least monosubstituted with C1-C6-alkyl, C1-C6-alkoxy, halogen, trifluoromethyl, trifluoromethoxy or OH;
• R1 and R2, independently from each other, are
• hydrogen;
• unsubstituted or at least monosubstituted C1-C10-alkyl, C3-C10-cycloalkyl, aryl, aryl-(C1-C10-alkyl)-, C2-C10-alkenyl, C2-C10-alkinyl, heterocyclyl, heterocyclyl-(C1-C10-alkyl)- or heteroaryl, where the substituents are chosen from halogen, C1-C6-alkyl, C1-C6-alkoxy, CN, NO2, NH2, (C1-C6-alkyl) amino-, di(C1-C6-alkyl)amino-, OH, COOH, —COO—(C1-C6-alkyl), —CONH2, formyl, trifluoromethyl and trifluoromethoxy;
• heteroaryl is a 5 to 10-membered, aromatic, mono- or bicyclic heterocycle containing one or more heteroatoms chosen from N, O and S;
• aryl is phenyl, indanyl, indenyl or naphthyl;
• heterocyclyl is a 5 to 10-membered, aliphatic, mono- or bicyclic heterocycle containing one or more heteroatoms chosen from N, O and S;
• or the racemates, enantiomers, diastereoisomers and mixtures thereof, the tautomers or the physiologically acceptable salts thereof;
• with the proviso that A is not —C(O)NH(C1-C6-alkyl), when Ar is phenyl which is at least monosubstituted with heterocyclyl or heteroaryl containing nitrogen.