Benzene acetamide compounds useful as serine protease inhibitors

A compound according to formula (I),

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• or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein:
• X is —OH, —O(alkyl), —O(aryl), —O(arylalkyl), —NR5(aryl), or —NR5(arylalkyl);
• wherein said aryl or arylalkyl are optionally substituted with one to two R25;
• W is hydrogen or —(CR7R8)q—H;
• Z is a 5-membered heteroaryl group optionally substituted with 1-3 R9, a five to six membered heterocyclo or cycloalkyl group optionally substituted with 1-3 R9, a 9 to 10 membered bicyclic aryl or heteroaryl optionally substituted with 1-3 substituents selected from R9 and/or R10, or
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• Z, Z2 and Z3 are independently N or CR9;
• R1, R2 and R3 are attached to any available carbon atom of phenyl ring A and are independently selected from hydrogen, halogen, cyano, nitro, C1-10alkyl, C2-10alkenyl, substituted C1-10alkyl, substituted C2-10alkenyl, —C(═O)NR12R13, —OR12, —CO2R12, —C(═O)R12, —SR12, —S(O)tR15, —NR12R13, —NR12SO2R15, —NR14SO2NR12R13, —NR12CO2R13, —NR12C(═O)R13, —NR14C(═O)NR12R13, —SO2NR12R13, aryl, heteroaryl, cycloalkyl, and heterocyclo;
• R5 is hydrogen, C1-4alkyl, NH2, C1-4alkylamino, hydroxy, or C1-4alkoxy;
• R7 and R8 are independently selected from hydrogen, —OR18, —NR18R19, —NR18SO2R20, alkyl, alkenyl, substituted alkyl, substituted alkenyl, halogen, haloalkyl, haloalkoxy, cyano, nitro, alkylthio, —C(═O)H, acyl, —CO2H, alkoxycarbonyl, sulfonamido, sulfonyl, and phenyl in turn optionally substituted with 1-3 of halogen, cyano, haloalkyl, haloalkoxy, nitro, hydroxy, C1-4alkyl, C1-4hydroxyalkyl, C1-4alkoxy, amino, NH(C1-4alkyl), N(C1-4alkyl)2, and/or C1-4aminoalkyl;
• R9, R10 and R11 are independently selected from hydrogen, halogen, alkyl, substituted alkyl, haloalkyl, haloalkoxy, cyano, nitro, —S(O)uR21, —NR22SO2R21, —C(═O)NR22R23, —OR22, —CO2R22, —C(═O)R22, —SR22, —NR22R23, —NR22CO2R23, —NR22C(═O)R23, —NR22C(═O)NR23R24, —SO2NR22R23, —NR22SO2NR23R24, —C(═NR22)NR23R24, five or six membered heterocyclo or heteroaryl, phenyl, and C3-7cycloalkyl, provided that R11 is not —C(═NR22)NR23R24 when W or W1 is hydrogen;
• wherein when R9, R10 or R11 is selected from heterocyclo, heteroaryl, phenyl, and C3-7cycloalkyl, each of said cyclic groups in turn is optionally substituted with up to three of C1-4alkyl, C1-4alkoxy, C1-4 hydroxyalkyl, C1-4 aminoalkyl, halogen, hydroxy, haloalkyl, haloalkoxy, amino, C1-4 alkylamino, and/or cyano;
• R12, R13, R14, R18, R19, R22 R23, and R24 are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, heteroaryl, cycloalkyl, and heterocyclo;
• R15, R20 and R21 are independently selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, heteroaryl, cycloalkyl, and heterocyclo;
• R25 at each occurrence is selected from hydrogen, halogen, cyano, nitro, C1-10alkyl, C2-10alkenyl, substituted C1-10alkyl, substituted C2-10alkenyl, —C(═O)NR12R13, —OR12, —CO2R12, —C(═O)R12, —SR12, —S(O)tR15, —NR12R13, —NR12SO2R15, —NR14SO2NR12R13, —NR12CO2R13, —NR12C(═O)R13, —NR14C(═O)NR12R13, —SO2NR12R13, aryl, heteroaryl, cycloalkyl, and heterocyclo;
• p is 1 or 2;
• q is 1, 2 or 3;
• t is 1 or 2;
• and
• u is 1 or 2;
• provided that when Z is phenyl, pyridyl or pyridazinyl, R9, R10 and/or R11 are other than cyano or —C(═NR22)NR23R24.