Pde IV inhibitors

A compound of the formula (1):

• 8
• wherein:
• A is methylene, lower alkylmethylene, carbonyl, hydroxymethylene or lower alkylcarbonyloxymethylene,
• Y is a 5- or 6-membered heteroaryl group containing one or two ring heteroatoms selected from nitrogen, sulfur and oxygen,
• Z is
• i) a fused ring in which any of 5- or 6-membered heteroaryl groups is fused to a benzene ring, or
• ii) a phenyl group which may be unsubstituted or optionally substituted with one or more members selected from the group consisting of halogen, cyano, nitro, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower alkyl, trifluoromethyl, hydroxyl, lower alkoxy, a residue derived from a carboxylic acid or a derivative thereof, amino, and an amino nitrogen-containing group,
• provided that
• when A is methylene, Y is a 5- or 6-membered heteroaryl group selected from the group consisting of pyrrolyl, pyridyl, 1-oxypyridyl, thienyl, furyl, imidazolyl, thiazolyl, and oxazolyl, and Z is a phenyl group which may be unsubstituted or substituted, the substituent on said phenyl group is amino, or an amino nitrogen-containing group;
• or a pharmaceutically acceptable salt thereof.