Use of taurolidine to treat tumors
AssigneeGeistlich Phama AG
InventorsPaul Calabresi, James Darnowski
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Abstract
The invention provides a method of inhibiting tumor growth in a mammal by, administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
Claims77
A method of inhibiting growth of an autologous tumor in a mammal, comprising administering to said mammal a composition comprising taurolidine or a biologically active derivative thereof.
A method of growth of an autologous tumor in a mammal, comprising administering to said mammal a composition comprising taurultam or a biologically active derivative thereof.
A method of inhibiting growth of a drug resistant tumor in a mammal, comprising administering to said mammal a composition comprising taurolidine or a biologically active derivative thereof.
A method of treating a drug resistant tumor in a mammal, comprising administering to said mammal a composition comprising taurultam or a biologically active derivative thereof.
A method of killing a tumor cell in a mammal, comprising administering to said mammal a composition comprising taurolidine, taurultam or a biologically active derivative thereof, wherein said composition is administered to directly contact the surface said tumor cell at a dose sufficient to induce tumor cell death by apoptosis.
A method of purging a population of bone marrow cells of tumor cells ex vivo, comprising contacting said population with a composition comprising taurolidine, taurultam, or a biologically active derivative thereof.
A method of purging a population of peripheral blood mononuclear cells of tumor cells, comprising contacting said population with a composition comprising taurolidine, taurultam, or a biologically active derivative thereof.
A therapeutic film-forming composition comprising taurolidine, taurultam, or a biologically active derivative thereof.
A method of treating a tumor in a mammal, comprising contacting a tumor cell in said mammal with a composition comprising taurolidine, taurultam, or a biologically active derivative thereof in an amount sufficient to initiate transduction of a cell surface signal, wherein said signal induces apoptotic death of said cell.
A method of inhibiting growth of a myelodysplastic cell in a mammal, comprising administering to said mammal a composition comprising taurolidine, taurultam or a biologically active derivative thereof.
Dependencies are inferred from the claim text.