Intranasal Benzodiazepine compositions
AssigneeUniversity of Kentucky Research Foundation
InventorDaniel P. Wermeling
Life of this patent
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Abstract
A pharmaceutical composition for intranasal administration to a mammal. The pharmaceutical composition comprises an effective amount of a benzodiazepine or pharmaceutically acceptable salt thereof; and a nasal carrier. In some embodiments, the pharmaceutical composition when administered intranasally produces a rapid physiological response. Pharmaceutical compositions may also include at least one or more sweeteners, flavoring agents, or masking agents or combinations thereof.
Claims26
A pharmaceutical composition for intranasal administration comprising:
- an effective amount of a benzodiazepine or pharmaceutically acceptable salt thereof;
- a nasal carrier;
- and at least one or more sweeteners, flavoring agents, or masking agents or combinations thereof.
A pharmaceutical composition for intranasal administration to a mammal comprising:
- an effective amount of midazolam or pharmaceutically acceptable salt thereof, polyethylene glycol, saccharin powder, and propylene glycol.
A method of treating a mammal in need of rapid sedation, anxiolysis, amnesia, or induction of anesthesia comprising intranasally administering to the mammal an effective amount of a pharmaceutical composition comprising midazolam or pharmaceutically acceptable salt thereof;
- and a nasal carrier;
- wherein the rapid sedation, anxiolysis, amnesia, or induction of anesthesia occurs within 5 minutes after intranasal administration.
A method of treating a mammal in need of rapid sedation, anxiolysis, amnesia, or induction of anesthesia comprising intranasally administering to the mammal an effective amount of a pharmaceutical composition comprising midazolam or pharmaceutically acceptable salt thereof;
- a nasal carrier;
- and at least one or more sweeteners, flavoring agents, or masking agents or combinations thereof.
A method of making a pharmaceutical composition for intranasal administration comprising adding at least one or more sweeteners, flavoring agents, or masking agents or combinations thereof to a pharmaceutical composition comprising midazolam or pharmaceutically acceptable salt thereof, and a nasal carrier so as to make the pharmaceutical composition.
Dependencies are inferred from the claim text.