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US 2004/0176358 A1Published application
Compositions and methods relating to novel compounds and targets thereof
AssigneeThe Regents of the University of Michigan
InventorGary D. Glick
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.
Claims5
A composition comprising a drug-eluting stent media;
- wherein said drug-eluting stent media comprises a pharmaceutical composition;
- wherein said pharmaceutical composition comprises an agent comprising the following formula:
- 67
- including both R and S enantiomeric foms and racemic mixtures;
- wherein R1, R2, R3 and R4 are selected from the group consisting of:
- hydrogen;
- CH3;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 1 carbon;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one hydroxy subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one thiol subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, wherein said aliphatic chain terminates with an aldehyde subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one ketone subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons;
- wherein said aliphatic chain terminates with a carboxylic acid subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one amide subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one acyl group;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one nitrogen containing moiety;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one amine subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one ether subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one halogen subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one nitronium subgroup;
- wherein R5 is selected from the group consisting of:
- OH;
- NO2;
- OR′;
- wherein
- R′ is selected from the group consisting of:
- a linear or branched, saturated or unsaturated aliphatic chain having at least one carbon;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one hydroxyl subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one thiol subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, wherein said aliphatic chain terminates with an aldehyde subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one ketone subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons;
- wherein said aliphatic chain terminates with a carboxylic acid subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one amide subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one acyl group;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one nitrogen containing moiety;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one amine subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one halogen subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one nitronium subgroup;
- wherein R6 is selected from the group consisting of:
- Hyrdrogen;
- NO2;
- Cl;
- F;
- Br;
- I;
- SR′;
- and NR′2;
- wherein R′ is defined as above in R5;
- wherein R7 is selected from the group consisting of:
- Hydrogen;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons;
- and
- wherein R8 is an aliphatic cyclic group larger than benzene;
- wherein said larger than benzene comprises any chemical group containing 7 or more non-hydrogen atoms, and is an aryl or aliphatic cyclic group.
53 more elements
A method of regulating cellular death comprising:
- a) providing a subject and a composition;
- wherein said composition comprises the following formula:
- 68
- including both R and S enantiomeric foms and racemic mixtures;
- wherein R1, R2, R3 and R4 are selected from the group consisting of:
- hydrogen;
- CH3;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 1 carbon;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one hydroxy subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one thiol subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, wherein said aliphatic chain terminates with an aldehyde subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one ketone subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons;
- wherein said aliphatic chain terminates with a carboxylic acid subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one amide subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one acyl group;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one nitrogen containing moiety;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one amine subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one ether subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one halogen subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one nitronium subgroup;
- wherein R5 is selected from the group consisting of:
- OH;
- NO2;
- OR′;
- wherein
- R′ is selected from the group consisting of:
- a linear or branched, saturated or unsaturated aliphatic chain having at least one carbon;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one hydroxyl subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one thiol subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, wherein said aliphatic chain terminates with an aldehyde subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one ketone subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons;
- wherein said aliphatic chain terminates with a carboxylic acid subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one amide subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one acyl group;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one nitrogen containing moiety;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one amine subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one halogen subgroup;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons, and having at least one nitronium subgroup;
- wherein R6 is selected from the group consisting of:
- Hyrdrogen;
- NO2;
- Cl;
- F;
- Br;
- I;
- SR′;
- and NR′2;
- wherein R′ is defined as above in R5;
- wherein R7 is selected from the group consisting of:
- Hydrogen;
- a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons;
- and
- wherein R8 is an aliphatic cyclic group larger than benzene;
- wherein said larger than benzene comprises any chemical group containing 7 or more non-hydrogen atoms.
- b) administering said composition to said subject.
54 more elements
Dependencies are inferred from the claim text.