Substituted heterocyclic compounds

A compound of the formula:

• 24
• wherein:
• R1 and R2 are independently optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;
• A is —(CR9R10)m—;
• in which m is 1 or 2;
• and
• R3, R4, R5, R6, R7, R8, R9, and R10, are independently hydrogen, optionally substituted lower alkyl, or —C(O)R;
• in which R is —OR11 or —NR11R12, where R11 and R12 are hydrogen or optionally substituted lower alkyl;
• or
• R3 and R4, R5 and R6, R7 and R8, R9 and R10, when taken together with the carbon to which they are attached, represent carbonyl;
• or
• R3 and R7, or R3 and R9, or R3 and R11, or R5 and R7, when taken together form a bridging group —(CR13R14)n—, in which n is 1, 2 or 3, and R13 and R14 are independently hydrogen or optionally substituted lower alkyl;
• with the proviso that the maximum number of carbonyl groups is 1;
• the maximum number of —C(O)NR11R12 groups is 1;
• and
• the maximum number of bridging groups is 1;
• T is oxygen or sulfur;
• X is a covalent bond or —(CR15R16)p—, in which R15 and R6 are hydrogen, optionally substituted lower alkyl, or —C(O)OR17 and p is 1, 2 or 3, in which R17 is hydrogen, optionally substituted lower alkyl, or optionally substituted phenyl;
• Y1 and Y2 are independently —(CR18R19)q—, in which q is 1, 2 or 3 and R18 and R19 are independently hydrogen, hydroxy, or optionally substituted lower alkyl;
• with the proviso that R18 and R19 are not hydroxy when q is 1;
• and
• Z is a covalent bond, —C(O)NR20—, or —NR20C(O)—, where R20 is hydrogen or optionally substituted lower alkyl;
• or
• Y2 and Z taken together are a covalent bond;
• with the proviso, that when R1 and R2 are optionally substituted phenyl and X is a covalent bond, Z is not a covalent bond.