Treatment of congestive heart failure
OwnerRebecca Guggemos Bakker-Arkema, Milton Lethan Presslerinventors
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Abstract
Combinations of diuretics and vasopressin antagonists are useful to slow and reverse the symptoms and process of congestive heart failure, to increase the excretion of water in the urine, and to decrease the excretion of sodium and potassium ions in urine. Preferred vasopressin antagonists have the formula 1 wherein R and R5 are hydrogen or lower alkyl; R1, R2, and R3 are hydrogen, halo, alkyl, alkoxy, and amino; and R4 is hydrogen or phenyl, and a pharmaceutically acceptable salt thereof.
Claims15
A pharmaceutical composition comprising an effective amount of a diuretic agent and an effective amount of a vasopressin antagonist.
A method for preventing and treating congestive heart failure and other edematous conditions in a mammal comprising administering an effective amount of a combination of at least one diuretic agent and at least one vasopressin antagonist.
A method for inhibiting excretion of sodium ions in the urine of an animal comprising administering to the animal an effective amount of a diuretic in combination with a vasopressin antagonist.
A method for inhibiting the excretion of potassium ions in the urine of an animal comprising administering to the animal an effective amount of a diuretic in combination with a vasopressin antagonist.
A method for treating edematous states in an animal comprising administering an effective amount of a diuretic agent in combination with a vasopressin antagonist.
Dependencies are inferred from the claim text.