Antibacterial composition
OwnerIain Simpson, Hans Rudolph Pfaendlerinventors
Life of this patent
Estimating the term…
Abstract
Disclosed is use of an oxenpenem-3-carboxylic acid of structure (I) or (II) as define above, in combination with an antibiotic and a pharmaceutically acceptable excipient, to prepare a medicament to treat an infection in a human or animal subject caused by a bacterium which does not produce a significant amount of β-lactamase.
Claims14
Use of an oxapenem-3-carboxylic acid of structure I or II or a salt, ester or amide derivative thereof:
- 4
- in combination with an antibiotic and a pharmaceutically acceptable excipient, to prepare a medicament to treat an infection in a human or animal (preferably mammalian) subject caused by a bacterium which does not produce a significant amount of β-lactamase, wherein R1 and R2 may, independently, be H, or a pharmaceutically acceptable group comprising from 1 to 10 carbon atoms being connected to the remainder of the molecule by a carbon-carbon single bond;
- and wherein each of R3, R4 and R5 is, independently, a pharmaceutically acceptable group comprising from 1 to 10 carbon atoms being connected to the remainder of the molecule by a carbon-carbon single bond.
A method of treating an infection in a human or animal subject caused by a bacterium which does not produce a significant amount of a β-lactamase, the method comprising administering to the subject an oxapenem-3-carboxylic acid of structure (I) or (II) as defined above or a salt, ester or amide derivative thereof, and an antibiotic.
A pharmaceutical composition for administration to a human or animal subject, comprising:
- an oxapenem-3-carboxylic acid of structure (I) or (II) defined above or a salt, ester or amide derivative thereof;
- an antibiotic which is substantially resistant to degradation by a β-lactamase;
- and a pharmaceutically acceptable excipient.
A method of treating a bacterial infection in a human or animal subject, the method comprising administering to the subject an oxapenem-3-carboxylic acid of structure (I) or (II) defined above or a salt, ester or amide derivative thereof, and an antibiotic which is substantially resistant to degradation by a β-lactamase.
Use of an oxapenem-3-carboxylic acid of structure (I) or (II) defined above or a salt, ester or amide derivative thereof, in combination with an antibiotic substantially resistant to degradation by a β-lactamase, and a pharmaceutically acceptable excipient, to prepare a medicament to treat a bacterial infection in a human or animal subject.
Use of an oxapenem-3-carboxylic acid of structure (I) or (II) defined above or a salt, ester or amide derivative thereof, in combination with an antibiotic and a pharmaceutically acceptable excipient, to prepare a medicament substantially as defined above.
A pharmaceutical composition for administration to a human or animal subject, comprising:
- an oxapenem-3-carboxylic acid of structure (I) or (II) defined above or a salt, ester or amide derivative thereof, in combination with an antibiotic which is substantially resistant to degradation by β-lactamase, and a pharmaceutically acceptable excipient, substantially as defined above.
Dependencies are inferred from the claim text.