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US 2004/0176346 A1Published application
Cytostatic lanthanum compounds
AssigneeFaustus Forschungs Cie. Translational Cancer Research GmbH
InventorBernhard Keppler
Life of this patent
Estimating the term…
Abstract
Lanthanum compounds are provided having general formulas (I) Rni+Yin− and (II) Rb+Yb− which may be used as medicaments in the prophylaxis and/or treatment of cancer diseases. In formula (I), R is a group of general formula (A): 1 and in general formula (II) Rb is a group of general formula (B): 2
Claims6
A compound of general formula (I)
- Rni+Yin− (I),
- wherein R is a group of general formula (A):
- 14
- wherein
- R1 and R3 are independently selected from the substituted and unsubstituted group consisting of C1-C10-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkenyl, C2-C10-alkenyl, C6-C14-aryl and a heterocycle, and hydrogen;
- R2 is selected from the substituted and unsubstituted group consisting of C1-C6-alkylene, C3-C6-cycloalkylene, C3-C6-cycloalkenylene, C2-C6-alkenylene, C6-C14-arylene and a heterocycle;
- R1 and R2 and/or R2 and R3 can form an heterocycle optionally containing further nitrogen atoms;
- Y is a physiologically compatible anion;
- i and n are independently natural numbers ≧1, and
- physiologically compatible addition salts,
- provided that R is not:
- 15
- 16
- and that if Y is NO3−R is not
- 17
- and
- that if Y is NO3−, CIO4− or CI−, R is not
- 18
15 more elements
A medicament, containing a compound of general formula (I)
- Rni+Yin− (I),
- wherein R is a group of the general formula (A)
- 19
- wherein
- R1 and R3 are independently selected from the substituted and unsubstituted group consisting of C1-C10-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkenyl, C2-C10-alkenyl, C6-C14-aryl and a heterocycle, and hydrogen;
- R2 is selected from the substituted and unsubstituted group consisting of C1-C6-alkylene, C3-C6-cycloalkylene, C3-C6-cycloalkenylene, C2-C6-alkenylene, C6-C14-arylene and a heterocycle;
- R1 and R2 and/or R2 and R3 can form an heterocycle optionally containing further nitrogen atoms;
- Y is a physiologically compatible anion;
- i and n are independently natural numbers ≧1, and
- physiologically compatible addition salts.
7 more elements
Dependencies are inferred from the claim text.