Method for preventing or reducing collateral phototoxic damage to neighboring tissues during photodynamic therapy of a target tissue
AssigneeNew York University
InventorGad Lavie
Life of this patent
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Abstract
A method is provided for preventing or reducing the adverse effects of photodynamic therapy such as collateral damage by regulating the localized phototoxicity of an effector photosensitizer molecule. During photodynamic therapy, the activity of the effector photosensitizer molecule in neighboring tissues of the tissue targeted for destruction is quenched by a quenching photosensitizer molecule.
Claims13
A method for regulating the localized phototoxicity of an effector photosensitizer molecule during photodynamic therapy by quenching the activity of the effector photosensitizer molecule in neighboring tissues of the tissue targeted for destruction, comprising administering to a patient in need thereof a quenching photosensitizer molecule, the absorption spectrum of which falls outside the wavelength range used to excite the effector photosensitizer molecule, prior to administering the effector photosensitizer molecule and performing photodynamic therapy.
A method for preventing adverse effects to neighboring tissues during photodynamic occlusion of blood vessels by an effector photosensitizer molecule, comprising administering to a patient in need thereof a quenching photosensitizer molecule that possesses a long tissue half-life and quenches the photodynamic activity of the effector photosensitizer molecule to prevent or reduce the formation of reactive oxygen species in neighboring tissues during photodynamic therapy.
Dependencies are inferred from the claim text.