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US 2004/0176342 A1Published application
Fluticasone lotion having improved vasoconstrictor activity
AssigneeGlaxo Wellcome Inc.
InventorsGordon J. Dow, Keith Arthur Johnson, Frances Furr Kelly, Robert William Lathrop, Rukmini Rajagopalan
Life of this patent
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Abstract
A fluticasone lotion having improved vasoconstrictor and anti-inflammatory activity and higher than expected potency. The fluticasone lotion contains 0.05 weight percent fluticasone propionate and an oil-in-water vehicle that includes excipients. The fluticasone lotion is unexpectedly efficacious while exhibiting an improved safety profile.
Claims24
A topical lotion comprising:
- about 0.005 to 1.0 wt. % fluticasone, or a pharmaceutically acceptable salt or ester thereof;
- about 1.0 to 10.0 wt. % of a C14-C20 fatty alcohol or mixtures thereof;
- about 1.0 to 5.0 wt. % of at least one skin conditioning agent;
- about 5.0 to 15.0 wt. % propylene glycol;
- up to about 10.0 wt. % mineral oil or white soft paraffin;
- and
- the balance in water.
4 more elements
A topical lotion comprising:
- about 0.005 to 1.0 wt. % fluticasone propionate;
- about 3.0 to 7.0 wt. % of a C14-C20 fatty alcohol, or mixtures thereof;
- about 0.5 to 3.0 wt. % of at least one skin conditioning agent;
- about 0.25 to 2.0 wt. % of at least one surfactant;
- about 7.0 to 12.0 wt. % propylene glycol;
- up to about 10 wt. % of mineral oil or white soft paraffin;
- and
- the balance in water.
5 more elements
A topical lotion comprising:
- about 0.005 to about 1.0 wt. % fluticasone, or d pharmaceutically acceptable salt or ester thereof;
- a thickening effective concentration of at least one thickener;
- a conditioning effective concentration of at least one skin conditioning agent;
- an emulsifying effective amount of a surfactant, and
- the balance in water.
2 more elements
A method of treating a skin condition comprising:
- providing a lotion including about 0.005 to about 1.0 wt. % fluticasone, or a pharmaceutically acceptable salt or ester thereof;
- about 1.0 to about 10.0 wt. % of a C14-C20 fatty alcohol or mixtures thereof;
- about 1.0 to about 5.0 wt. % of at least one skin conditioning agents;
- about 5.0 to about 15.0 wt. % of propylene glycol;
- less than about 10.0 wt. % of mineral oil or white soft paraffin, and the balance in water;
- and,
- applying the lotion to the skin having the skin condition.
4 more elements
Dependencies are inferred from the claim text.