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AssigneeWockhardt Limited
InventorsDilip G. Saoji, Rajendra N. Nagori, Milind C. Shukla, Sachin Bhagwat, Shrikant V. Gupte, Mahesh V. Patel, Rasendrakumar Jha, Anil Kukreja, Noel J. De Souza
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This invention relates to topical compositions of an antibacterial benzoquinolizine-2-carboxylic acid, incorporated either as the single therapeutic ingredient in hitherto undescribed pharmaceutical compositions, or as an ingredient in novel combination with at least one agent selected from a retinoid, an antifungal agent, another antibacterial compound and/or a steroid/non-steroid anti-inflammatory agent, to processes for preparation of the compositions, to use of the compositions in preparation of a medicament, and to a method of therapeutic or prophylactic use of such a composition for the treatment of dermal, ophthalmic, otic and nasal infections, with or without attendant inflammation.
A stable pharmaceutical composition comprising:
The method of claim 33, wherein the benzoquinolizine-2-carboxylic acid antimicrobial drug is RS-(±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid arginine salt and solvatomorphic or polymorphic forms thereof.
The method of claim 33, wherein the benzoquinolizine-2-carboxylic acid antimicrobial drug is S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid arginine salt and solvatomorphic or polymorphic forms thereof.
The method of claim 33, wherein the benzoquinolizine-2-carboxylic acid antimicrobial drug is S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid 0.2 hydrate.
The method of claim 33, wherein the benzoquinolizine-2-carboxylic acid antimicrobial drug is S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid.
The method of claim 33, wherein the benzoquinolizine-2-carboxylic acid antimicrobial drug comprises about 0.1-10% by weight of the composition.
The method of claim 33, wherein the benzoquinolizine-2-carboxylic acid antimicrobial drug comprises about 1% by weight of the composition.
The method of claim 33, wherein the benzoquinolizine-2-carboxylic acid antimicrobial drug comprises about 0.5% by weight of the composition.
The method of claim 33, wherein the retinoid comprises adapalene.
The method of claim 33, wherein said antibacterial is selected from the classes of aminoglycosides, cephalosporins, diaminopyridines, oxazolidinones, sulfonamides, tetracyclines or combinations of these classes.
The method of claim 33, wherein the steroid comprises clobetasol.
The method of claim 33, wherein said non-steroid antiinflammatory agent is selected from the group consisting essentially of ibuprofen, indomethacin, ketoprofen, flurbiprofen, celecoxib, valdecoxib, rofecoxib, varecoxib, parecoxib, meloxicam, nimesulide, etodolac, combinations and mixtures thereof.
Dependencies are inferred from the claim text.