Drugs for promoting the proliferation, differentiation and/or survival of glial cells containing cyclic phosphatidic acid
OwnerKimiko Murofushi, Hiroaki Asou +1inventors
InventorsKimiko Murofushi, Hiroaki Asou, Tetsuyuki Kobayashi
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Abstract
An object of the present invention is to reveal an action of cPA on glial cells as a new physiological activity of cPA and to reveal the possibility of cPA as a medicament for treating a brain nerve disease including Alzheimer's disease, ischemic nerve disease, and Parkinsonism, and particularly cerebrovasucular dementia such as Binswanger's disease type dementia. According to the present invention, there is provided a medicament for treating cerebrovascular dementia, which comprises a cyclic phosphatidic acid derivative having a cyclic phosphoric acid structure at the sn-2 and 3 positions of glycerol.
Claims6
A medicament for promoting the proliferation, differentiation and/or survival of glial cells, which comprises a cyclic phosphatidic acid derivative represented by the formula (I) as an active ingredient:
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- wherein R is a C1-30 linear or branched alkyl group, a C2-30 linear or branched alkenyl group, or a C2-30 linear or branched alkynyl group, wherein these groups may contain a cycloalkane ring or an aromatic ring;
- and M is a hydrogen atom or a counter cation.
A medicament for treating and/or preventing a nerve disease associated with decrease of the glial cells which comprises a cyclic phosphatidic acid derivative represented by the formula (I) as an active ingredient:
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- wherein R is a C1-30 linear or branched alkyl group, a C2-30 linear or branched alkenyl group, or a C2-30 linear or branched alkynyl group, wherein these groups may contain a cycloalkane ring or an aromatic ring;
- and M is a hydrogen atom or a counter cation.
Dependencies are inferred from the claim text.