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US 2004/0176316 A1Published application
Compounds for the normalization of the sleep/wake cycle
OwnerPerry F. Renshaw, Scott Lukasinventors
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OwnerPerry F. Renshaw, Scott Lukasinventors
Estimating the term…
The invention provides methods for normalizing the sleep/wake cycle of a mammal by administering a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, uridine-containing compound, creatine-containing compound, adenosine-containing, or adenosine-elevating compound. As such the methods described herein may increase wakefulness, reduce tiredness or fatigue during the day, and improve sleep quality. The methods of the invention may also be used in the treatment of sleep disorders, such as insomnia, sleep apnea, periodic limb movements, restless leg syndrome, narcolepsy, and problem sleepiness, or for increasing cognitive function in sleep deprived individuals. Citicoline is an exemplary compound for use in the methods described herein.
A method of normalizing the sleep/wake cycle of a mammal, said method comprising administering a therapeutically-effective amount of a compound selected from the group consisting of a cytidine-containing compound, a cytosine-containing compound, a uridine-containing compound, a creatine-containing compound, an adenosine-containing compound, and an adenosine-elevating compound to a mammal, thereby normalizing the sleep/wake cycle of said mammal.
A method of treating a sleep disorder, said method comprising administering to a mammal a therapeutically-effective amount of a compound selected from the group consisting of a cytidine-containing compound, a cytosine-containing compound, a uridine-containing compound, a creatine-containing compound, an adenosine-containing compound, and an adenosine-elevating compound.
A method of increasing cognitive function, said method comprising administering a therapeutically-effective amount of a compound selected from the group consisting of a cytidine-containing compound, a cytosine-containing compound, a uridine-containing compound, a creatine-containing compound, an adenosine-containing compound, and an adenosine-elevating compound to a mammal suffering from sleep deprivation, thereby increasing the cognitive functioning of said mammal.
Dependencies are inferred from the claim text.