Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor

A glucopyranosyloxypyrazole derivative represented by the general formula:

• 20
• wherein R11 is a hydrogen atom or an optionally protected hydroxy (C2-6 alkyl) group;
• one of Q and T is 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy group and the other is a C1-6 alkyl group, a halo(C1-6alkyl) group, a C1-6 alkoxy-substituted (C1-6 alkyl) group or a C3-7 cycloalkyl group;
• and R23 is a halogen atom, an optionally protected hydroxy group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, a halo(C1-6 alkyl) group, a halo(C1-6alkoxy) group, a C1-6alkoxy-substituted (C1-6 alkoxy) group, a C3-7cycloalkyl-substituted (C2-6alkoxy) group or a group of the general formula:
• -A-R32 wherein A is a single bond, an oxygen atom, a methylene group, an ethylene group, —OCH2— or —CH2O—;
• and R32 is a C3-7 cycloalkyl group, a C3-7 heterocycloalkyl group, an aryl group which may have 1-3 the same or different substituents selected from a halogen atom, an optionally protected hydroxy group, an optionally protected amino group, a C1-6 alkyl group, a C1-6 alkoxy group, a C2-6 alkenyloxy group, a halo(C1-6 alkyl) group, an optionally protected hydroxy(C1-6 alkyl) group, an optionally protected carboxy group, a C2-7 alkoxycarbonyl group, a cyano group and a nitro group, a thiazolyl group which may have a substituent selected from a halogen atom and a C1-6 alkyl group, or a pyridyl group which may have a substituent selected from a halogen atom and a C1-6 alkyl group, or a salt thereof.

A glucopyranosyloxypyrazole derivative represented by the general formula:

• 21
• wherein R11 is a hydrogen atom or an optionally protected hydroxy (C2-6 alkyl) group;
• one of Q3 and T3 is a hydroxy group and the other is a C1-6 alkyl group, a halo(C1-6 alkyl) group, a C1-6 alkoxy-substituted (C1-6alkyl) group or a C3-7 cycloalkyl group;
• and R23 is a halogen atom, an optionally protected hydroxy group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, a halo(C1-6 alkoxy) group, a halo(C1-6 alkyl) group, a C1-6 alkoxy-substituted (C1-6 alkoxy) group, a C3-7 cycloalkyl-substituted (C2-6alkoxy) group or a group of the general formula:
• -A-R32 wherein A is a single bond, an oxygen atom, a methylene group, an ethylene group, —OCH2— or —CH2O—;
• and R32 is a C3-7 cycloalkyl group, a C3-7 heterocycloalkyl group, an aryl group which may have 1-3 the same or different substituents selected from a halogen atom, an optionally protected hydroxy group, an optionally protected amino group, a C1-6 alkyl group, a C1-6 alkoxy group, a C2-6 alkenyloxy group, a halo(C1-6alkyl) group, an optionally protected hydroxy(C1-6 alkyl) group, an optionally protected carboxy group, a C2-7 alkoxycarbonyl group, a cyano group and a nitro group, a thiazolyl group which may have a substituent selected from a halogen atom and a C1-6 alkyl group, or a pyridyl group which may have a substituent selected from a halogen atom and a C1-6 alkyl group, or a salt thereof.