Method of regulating glucose metabolism, and reagents related thereto
AssigneeTrustees of Tufts College
InventorsWilliam W. Bachovchin, Andrew G. Plaut, Daniel Drucker
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Abstract
The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia, obesity, hyperlipidemia, hyperlipoprotein-emia (such as chylomicrons, VLDL and LDL), and to regulate body fat and more generally lipid stores, and, more generally, for the improvement of metabolism disorders, especially those associated with diabetes, obesity and/or atherosclerosis.
Claims37
A method for modifying, in an animal, metabolism of glucagon-like peptide 1 (GLP-1), comprising administering to the animal a composition including one or more inhibitors of a dipeptidylpeptidase which inactivates GLP-1, which inhibitor(s) are administered in an amount sufficient to inhibit the dipeptidylpeptidase proteolysis of GLP-1.
A method for modifying glucose metabolism of an animal, comprising administering to the animal a composition including one or more protease inhibitors which inhibit DPIV-mediated proteolysis with a Ki of 1 nM or less.
A method for modifying glucose metabolism of an animal, comprising administering to the animal a composition including one or more protease inhibitors which inhibit the proteolysis of glucagon-like peptide 1 (GLP-1) and accordingly increase the plasma half-life of GLP-1.
A method for treating Type II diabetes, comprising administering to an animal a composition including one or more inhibitors dipeptidylpeptidase IV (DPIV).
A method for modifiying, in an animal, metabolism of peptide hormone, comprising administering to the animal a composition including one or more inhibitors of dipeptidylpeptidase IV (DPIV) in an amount sufficient to increase the plasma half-life of a peptide hormone, which peptide hormone is selected from the group consisting of glucagon-like peptide 2 (GLP-2), growth hormone-releasing factor (GHRF), vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI), pituitary adenylate cyclase activating peptide (PACAP), gastric inhibitory peptide (GIP), helodermin, Peptide YY and neuropeptide Y.
A method for modifying glucose metabolism of an animal, comprising administering to the animal a composition including boronyl peptidomimetic of a peptide selected from the group consisting Pro-Pro, Ala-Pro, and (D)-Ala-(L)-Ala.
A method for modifying glucose metabolism of an animal, comprising administering to the animal a composition including boronyl inhibitor of peptidomimetic of a peptide selected from the group consisting Pro-Pro, Ala-Pro, and (D)-Ala-(L)-Ala.
Dependencies are inferred from the claim text.