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US 2004/0176299 A1Published application
Methods and compositions for the treatment of pancreatitis
AssigneeAllergan, Inc.
InventorsGeorge Sachs, Kei Roger Aoki
Life of this patent
Estimating the term…
Abstract
Methods and compositions for the treatment of acute pancreatitis in a mammal. Particular compositions comprise a binding element, a translocation element, and a therapeutic element able to prevent accumulation of digestive enzymes within the pancreas.
Claims40
A composition for the treatment of acute pancreatitis in a mammal comprising,
- a. a first element comprising a binding element able to specifically bind a pancreatic cell surface marker under physiological conditions,
- b. a second element comprising a translocation element able to facilitate the transfer of a polypeptide across a vesicular membrane, and
- c. a third element comprising a therapeutic element able, when present in the cytoplasm of a pancreatic cell, to inhibit enzymatic secretion by said pancreatic cell.
A method for the treatment of a mammal suffering from acute pancreatitis comprising:
- administering to said patient a pharmaceutically effective amount of a composition comprising a first element comprising a binding element able to specifically bind a pancreatic cell surface marker under physiological conditions, a second element comprising a translocation element able to facilitate the transfer of a polypeptide across a vesicular membrane, and a third element comprising a therapeutic element able, when present in the cytoplasm of a pancreatic cell, to inhibit enzymatic secretion by said pancreatic cell.
Dependencies are inferred from the claim text.