Method of promoting bone growth with hyaluronic acid and growth factors
AssigneeDepuy Acromed, Inc.
InventorMichael Radomsky
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Abstract
A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at an intra-articular site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4% by weight and preferred growth factor is bFGF, present in a concentration range of about 10-6 to 100 mg/ml.
Claims10
A composition for treatment of diseased, injured or abnormal bone composition comprising an effective amount of a mixture of a growth factor and hyaluronic acid sufficient to enhance bone growth rate and magnitude and having sufficient viscosity and biodegradability to persist upon application at an intra-articular site of desired bone growth for a period of time sufficient to enhance said bone growth rate and magnitude.
A method of treating diseased, injured or abnormal bone at an intra-articular site of desired bone growth comprising the step of applying to said site a composition comprising an effective amount of a mixture of hyaluronic acid and a growth factor sufficient to enhance bone growth rate and magnitude and having sufficient viscosity and biodegradability to persist at said site for a period of time sufficient to enhance said bone growth rate and magnitude.
Dependencies are inferred from the claim text.