Use of thyroid-stimulating hormone to induce lipolysis
OwnerJames D. Kellyinventor
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Abstract
The use of thyroid-stimulating hormone (TSH) to induce lipolysis, treat obesity, insulin resistance, liver steatosis, hyperlipidemia, and type-2 diabetes is described.
Claims35
A method for inducing lipolysis in a mammal comprising administering to the mammal a pharmaceutically effective amount of a TSH polypeptide, wherein administration of the polypeptide results in a clinically significant decrease in the body weight of the mammal.
A method for inducing weight loss in a mammal, comprising administering to the mammal a pharmaceutically effective amount of a TSH polypeptide, wherein administration of the polypeptide results in a clinically significant decrease in body weight of the mammal.
A method for treating type-2 diabetes in a mammal, comprising administering to the mammal a pharmaceutically effective amount of a TSH polypeptide, wherein administration of the polypeptide results in an improvement in the diabetic state of the mammal.
A method for treating hyperlipidemia in a mammal comprising administering to the mammal a pharmaceutically effective amount of a TSH polypeptide, wherein administration of the polypeptide results in decreased hyperlipidemia in the mammal.
A method for treating steatohepatitis in a mammal, comprising administering to the mammal a pharmaceutically effective amount of a TSH polypeptide, wherein administration of the polypeptide results in an improved steatohepatic state in the mammal.
A method for preventing steatohepatitis in a mammal with steatosis, comprising administering to the mammal a pharmaceutically effective amount of a TSH polypeptide, wherein administration of the polypeptide maintains or reduces the steatosis.
A method for lowering elevated plasma cholesterol levels in a mammal, comprising administering a pharmaceutically effective amount of a TSH polypeptide to said mammal, wherein administration of the polypeptide lowers the plasma cholesterol level in the mammal.
A method of lowering elevated triglyceride levels in a mammal, comprising administering a pharmaceutically effective amount of a TSH polypeptide to said mammal, wherein administration of the polypeptide lowers triglyceride levels in the mammal.
A method for treating steatosis of the liver in a mammal with steatosis, comprising administering to the mammal a pharmaceutically effective amount of a TSH polypeptide, wherein administration of the polypeptide maintains or reduces the steatosis.
A method for improving insulin sensitivity in a mammal comprising administering to the mammal a pharmaceutically effective amount of a TSH polypeptide, wherein administration of the polypeptide results in increased sensitivity to insulin.
A method for treating athersclerosis in a mammal comprising administering to the mammal a pharmaceutically effective amount of a TSH polypeptide, wherein administration of the polypeptide results in an improved athersclerotic state.
Dependencies are inferred from the claim text.